- 专利标题： Method of increasing the function of an AAV vector
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申请号： US16887833申请日： 2020-05-29
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公开(公告)号： US10947561B2公开(公告)日： 2021-03-16
- 发明人: Luk Vandenberghe , Guangping Gao , James M. Wilson
- 申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- 申请人地址： US PA Philadelphia
- 专利权人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- 当前专利权人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- 当前专利权人地址： US PA Philadelphia
- 代理机构： Howson & Howson LLP
- 代理商 Colleen M. Schaller
- 主分类号： C12N15/00
- IPC分类号： C12N15/00 ; C12N15/86 ; A61K48/00 ; C07K14/005 ; C12N7/00
摘要：
A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
公开/授权文献
- US20200325491A1 METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR 公开/授权日：2020-10-15
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