- 专利标题: Long-acting coagulation factors and methods of producing same
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申请号: US15737979申请日: 2016-06-19
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公开(公告)号: US10960058B2公开(公告)日: 2021-03-30
- 发明人: Udi Eyal Fima , Gili Hart
- 申请人: OPKO BIOLOGICS LTD.
- 申请人地址: IL Kiryat Gat
- 专利权人: OPKO BIOLOGICS LTD.
- 当前专利权人: OPKO BIOLOGICS LTD.
- 当前专利权人地址: IL Kiryat Gat
- 代理机构: Pearl Cohen Zedek Latzer Baratz LLP
- 代理商 Mark S. Cohen
- 国际申请: PCT/IL2016/050645 WO 20160619
- 国际公布: WO2016/203482 WO 20161222
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; C12Q1/56 ; A61K9/19 ; A61K9/64 ; A61P7/04 ; C07K14/59 ; A61K38/48 ; C12N9/64 ; A61K9/00
摘要:
Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.
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