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公开(公告)号：US09861586B2
公开(公告)日：2018-01-09
申请号：US15590369
申请日：2017-05-09
申请人： PATHEON SOFTGELS INC
IPC分类号： A61K9/64 , A61K9/48 , A61K9/00 , A61K31/19 , A61K31/135
CPC分类号： A61K9/4816 , A61K9/0056 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/19 , A61K31/192
摘要： A matrix formulation for a soft chewable capsule is provided which includes a gel-forming composition, a plasticizer, a polymer modifier, and water. The polymer modifier may be a carboxylic acid or other organic compound that alters the physical and/or chemical properties of the capsule formulation. A chewable soft capsule is also provided, having enhanced organo-leptic and processing properties. An active material may be delivered to a user using this dosage form. A method of forming the chewable soft capsule is also provided.
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公开(公告)号：US09757344B2
公开(公告)日：2017-09-12
申请号：US12656487
申请日：2010-02-01
申请人： Yasuki Kato , Masahiro Yamauchi , Hiroko Kusano , Takeshi Iwata , Takaaki Uochi , Shiro Akinaga
发明人： Yasuki Kato , Masahiro Yamauchi , Hiroko Kusano , Takeshi Iwata , Takaaki Uochi , Shiro Akinaga
IPC分类号： A61K9/19 , A61K9/64 , A61K9/51 , A61K9/14 , A61K9/127 , A61K9/50 , B01J13/12 , A61K31/7088 , A61K47/48
CPC分类号： A61K9/5123 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/141 , A61K9/146 , A61K9/5015 , A61K9/5192 , A61K31/7088 , A61K47/6911 , B01J13/12
摘要： A coated fine particle comprisisng: (i) a complex of a drug and a cationic lipid, wherein (a) the drug is a nucleic acid and the complex is obtained by mixing the drug and the cationic lipid in water, wherein the complex has a diameter of 10 nm to 1,000 nm, and (ii) a lipid layer formed of lipid(s), wherein the lipid(s) is selected from phospholipid, glyceroglycolipid, sphingoglycolipid, cholesterol and synthetic lipid, wherein the complex is coated with the lipid layer.
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公开(公告)号：US09668976B2
公开(公告)日：2017-06-06
申请号：US14790624
申请日：2015-07-02
IPC分类号： A61K9/64 , A61K9/48 , A61K31/192 , A61K31/135 , A61K9/00 , A61K31/137 , A61K31/167
CPC分类号： A61K9/4816 , A61K9/0056 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/19 , A61K31/192
摘要： A matrix formulation for a soft chewable capsule is provided which includes a gel-forming composition, a plasticizer, a polymer modifier, and water. The polymer modifier may be a carboxylic acid or other organic compound that alters the physical and/or chemical properties of the capsule formulation. A chewable soft capsule is also provided, having enhanced organo-leptic and processing properties. An active material may be delivered to a user using this dosage form. A method of forming the chewable soft capsule is also provided.
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4.发明授权Mucoadhesive particulate formulation for inducing antigen-specific immune tolerance 有权用于诱导抗原特异性免疫耐受的粘膜微粒制剂公开(公告)号：US09480748B2
公开(公告)日：2016-11-01
申请号：US14088168
申请日：2013-11-22
申请人： STALLERGENES S.A.
发明人： Nathalie Saint-Lu , Alain Razafindratsita , Sophie Tourdot , Philippe Moingeon , Laurence Van Overtvelt
IPC分类号： A01N25/26 , A01N25/28 , A61K9/54 , A61K9/62 , A61K9/64 , A61K39/35 , A61K39/36 , A61K47/36 , A61K9/00 , A61K9/16 , A61K9/51 , A61K9/14 , A61K39/00
CPC分类号： A61K47/36 , A61K9/006 , A61K9/146 , A61K9/1652 , A61K9/5161 , A61K39/35 , A61K2039/542 , A61K2039/55583
摘要： The present disclosure relates to a mucoadhesive composition, adapted for preventing and/or treating a pathological reaction of the immune system of an individual, by inducing a specific tolerance towards at least one antigen involved in said pathological reaction, comprising chitosan particles loaded with said at least one antigen involved in the pathological reaction, wherein the size of the loaded chitosan particles is of more than 800 nm.
摘要翻译： 本公开内容涉及通过对参与所述病理反应的至少一种抗原诱导特异性耐受性的方法，其适于预防和/或治疗个体的免疫系统的病理反应，所述粘膜粘附组合物包含装载有所述at 涉及病理反应的至少一种抗原，其中负载的壳聚糖颗粒的尺寸大于800nm。
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公开(公告)号：US09271520B2
公开(公告)日：2016-03-01
申请号：US13777662
申请日：2013-02-26
发明人： Jayant Deshpande
IPC分类号： A23L1/30 , A61K9/64 , A61K9/16 , A61K9/50 , A23L1/302 , A23L1/303 , A61K9/20 , A61K36/53 , A61K36/82 , A61K36/9066 , A61K36/9068
CPC分类号： A23L1/3002 , A23L33/105 , A23L33/115 , A23L33/155 , A61K9/1676 , A61K9/2081 , A61K9/5047 , A61K9/5078 , A61K36/53 , A61K36/82 , A61K36/9066 , A61K36/9068 , A61K2300/00
摘要： The invention disclosed in this application relates to novel stable beadlets of lipophilic nutrients comprising an inert core having a coating of stabilizing antioxidants, lipophilic nutrients, or mixtures thereof. The beadlets may be coated with one or more coatings to protect the lipophilic ingredients from the atmosphere, specifically the coatings can be used to protect against moisture and/or oxygen. The invention also relates to a process for the preparation of the stable beadlets. The beadlets can be used in medicines and dietary supplements intended to facilitate the reduced risk of macular degeneration, cataract, and several forms of cancer.
摘要翻译： 本申请中公开的发明涉及亲脂性营养物质的新型稳定珠粒，其包含具有稳定抗氧化剂，亲脂性营养物或其混合物的包衣的惰性核心。 珠粒可以涂覆有一种或多种涂层以保护亲脂成分从大气中，特别地，涂层可用于防止湿气和/或氧气。 本发明还涉及制备稳定珠粒的方法。 珠粒可用于药物和膳食补充剂，旨在促进黄斑变性，白内障和几种形式的癌症的风险降低。
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公开(公告)号：US08974821B2
公开(公告)日：2015-03-10
申请号：US13786109
申请日：2013-03-05
申请人： Durect Corporation
发明人： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton , Roger Fu , Michael S. Zamloot
IPC分类号： A61K9/64 , A61K31/44 , A61K47/00 , A61K9/48 , A61K31/485 , A61K47/26 , A61K31/4458
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
摘要： Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
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7.发明授权Apparatus and process for encapsulating microparticles with liquid in soft gel capsules 有权在软胶囊中用液体包裹微粒的装置和方法公开(公告)号：US08974820B2
公开(公告)日：2015-03-10
申请号：US13137051
申请日：2011-07-18
申请人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Willmer Herrera
发明人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Willmer Herrera
IPC分类号： A61K9/64 , A61K9/48 , A61K9/52 , A61K9/54 , A61K9/56 , A61K9/58 , A61K9/60 , A61K9/62 , A61J3/07
CPC分类号： A61J3/07 , A61K9/16 , A61K9/4808 , A61K9/4833 , A61K9/4883 , A61K9/51
摘要： The invention provides an apparatus for producing soft gel capsules having encapsulated therein microparticles, nanoparticles and fluids, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies; (d) a liquid fill system (medicine pump system); (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) one or more microgranule or nanogranule feeders located on each side of the rotary dies, said feeders being synchronized to rotate at the same tangential speed as the rotary dies.
摘要翻译： 本发明提供了一种用于生产软胶囊的装置，其中封装有微粒，纳米颗粒和流体，所述装置包括：（a）两个撒布盒; （b）两个铸桶; （c）一对旋转模具; （d）液体填充系统（药物泵系统）; （e）用于加热明胶带并进料所述填充物的楔子; 和（f）位于旋转模具的每一侧上的一个或多个微粒或纳米颗粒进料器，所述进料器同步以与旋转模具相同的切向速度旋转。
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8.发明授权公开(公告)号：US08597666B2
公开(公告)日：2013-12-03
申请号：US13284454
申请日：2011-10-28
申请人： Ilan Zalit , Fanny Leska , Mali Kadosh , Dorit Marco , Yonit Messer-Triger
发明人： Ilan Zalit , Fanny Leska , Mali Kadosh , Dorit Marco , Yonit Messer-Triger
CPC分类号： A61K9/2077 , A61K9/2059 , A61K31/445 , A61K31/55
摘要： A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.
摘要翻译： 低溶解度的化合物的药物制剂及其制造方法。 制剂可以包含具有低水溶性的药理活性化合物和大于约25重量％的量的淀粉。 制造方法可以包括混合活性化合物和淀粉，将共混物压制成固体，将固体粉碎成颗粒，润湿颗粒，干燥颗粒，并将干燥的颗粒压片以制成固体药物制剂。
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9.发明授权公开(公告)号：US08586076B2
公开(公告)日：2013-11-19
申请号：US13340879
申请日：2011-12-30
申请人： Joseph D. Artiss , Catherine Jen
发明人： Joseph D. Artiss , Catherine Jen
CPC分类号： A23L1/22091 , A21D2/181 , A21D2/186 , A21D13/80 , A23K20/163 , A23K50/40 , A23L5/273 , A23L7/111 , A23L7/126 , A23L9/12 , A23L15/30 , A23L25/10 , A23L27/88 , A23L29/35 , A23L33/20 , A23P10/30 , A23P30/40 , A61K31/724
摘要： This invention relates to fat containing consumable food products comprising α-cyclodextrin. The food products have reduced levels of bioavailable fat but have substantially the same fat, cholesterol and caloric content as a like food without α-cyclodextrin. The invention also relates to methods for reducing the bioavailability of fats in fat containing food products without reducing caloric intake as determined by bomb calorimetry and to methods for increasing high density lipoproteins in a subject and reducing or controlling weight by administering the food products of this invention.
摘要翻译： 本发明涉及包含α-环糊精的含脂肪的消费食品。 食品具有降低生物可利用脂肪的水平，但具有与没有α-环糊精的食物相似的脂肪，胆固醇和热量含量。 本发明还涉及降低含脂肪食品中脂肪的生物利用度的方法，而不通过炸弹量热法测定而不减少热量摄入，以及通过施用本发明的食品来降低或控制体重的方法 。
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公开(公告)号：US08568773B2
公开(公告)日：2013-10-29
申请号：US12934338
申请日：2009-06-24
申请人： Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled , Yael Richter
发明人： Gai Ben Dror , Dorit Platt , Orly Farkash , Rassan Zuabi , Zohar Bar-On , Avidor Shulman , Dori Pelled , Yael Richter
CPC分类号： A61K47/544 , A21D2/32 , A23D7/013 , A23D9/013 , A23L33/12 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K31/201 , A61K31/202 , A61K31/66 , A61K31/685 , C07F9/10 , A23V2200/322 , A23V2250/1882 , A23V2250/1942 , A23V2250/1842
摘要： The invention described herein provides a preparation comprising a non-mammalian derived mixture of serine glycerophospholipid conjugates with a specific content and specific conjugation patterns of LA, linolenic acid (alpha-linolenic acid, gamma-linolenic acid) DHA and EPA which depend on utilizing different sources of lipids, and uses of such preparations.
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