公开(公告)号：US10960058B2

公开(公告)日：2021-03-30

申请号：US15737979

申请日：2016-06-19

申请人： OPKO BIOLOGICS LTD.

发明人： Udi Eyal Fima ,  Gili Hart

IPC分类号： A61K38/00 ,  C12Q1/56 ,  A61K9/19 ,  A61K9/64 ,  A61P7/04 ,  C07K14/59 ,  A61K38/48 ,  C12N9/64 ,  A61K9/00

摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.

公开(公告)号：US20160310576A1

公开(公告)日：2016-10-27

申请号：US15200813

申请日：2016-07-01

申请人： OPKO Biologics Ltd.

发明人： Fuad FARES ,  Udi Eyal Fima

IPC分类号： A61K38/27 ,  G01N33/74 ,  A61K47/02 ,  A61K38/24 ,  A61K47/12

CPC分类号： A61K38/27 ,  A61K38/24 ,  A61K47/02 ,  A61K47/12 ,  C07K14/505 ,  C07K14/555 ,  C07K14/59 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31 ,  G01N33/74 ,  G01N2333/65 ,  G01N2800/52

摘要： CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.

公开(公告)号：US20150368630A9

公开(公告)日：2015-12-24

申请号：US13759860

申请日：2013-02-05

申请人： Opko Biologics Ltd.

发明人： Udi Eyal FIMA ,  Gili Hart

IPC分类号： C12N9/50

CPC分类号： C12N9/50 ,  A61K38/00 ,  A61K47/64 ,  C07K14/505 ,  C07K14/59 ,  C07K14/745 ,  C07K2319/02 ,  C07K2319/31 ,  C07K2319/91 ,  C12N9/6437 ,  C12N9/644 ,  C12Y304/21021

摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

摘要翻译： 公开了包含至少一个连接到羧基末端而不是凝固因子的氨基末端的绒毛膜促性腺激素的羧基末端肽（CTP）的多肽和编码该羧基末端肽的多核苷酸。 还公开了包含本发明的多肽和多核苷酸的药物组合物及其使用和生产方法。

公开(公告)号：US20150258208A1

公开(公告)日：2015-09-17

申请号：US14725883

申请日：2015-05-29

申请人： Opko Biologics Ltd.

发明人： Udi FIMA ,  Oren HERSHKOVITZ

IPC分类号： A61K47/48 ,  A61K38/26

CPC分类号： A61K47/48215 ,  A61K38/22 ,  A61K47/60

摘要： A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a reversible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed.

摘要翻译： 公开了包含通过可逆接头如9-芴基甲氧基羰基（Fmoc）或磺基-9-芴基甲氧基羰基（FMS）连接的胃泌酸调节素和聚乙二醇聚合物（PEG聚合物）的组合物。 还公开了包含反向聚乙二醇化的胃泌酸调节素的药物组合物及其使用方法。

公开(公告)号：US20150152155A1

公开(公告)日：2015-06-04

申请号：US14550346

申请日：2014-11-21

申请人： OPKO BIOLOGICS LTD.

发明人： Fuad FARES ,  Udi Eyal Fima

IPC分类号： C07K14/505 ,  C07K14/59

CPC分类号： C07K14/555 ,  A61K38/19 ,  A61K47/64 ,  C07K14/505 ,  C07K14/59 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/35 ,  C07K2319/91

摘要： A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.

公开(公告)号：US20150148291A1

公开(公告)日：2015-05-28

申请号：US14555258

申请日：2014-11-26

申请人： OPKO BIOLOGICS LTD.

发明人： UDI EYAL FIMA ,  GILI HART

IPC分类号： C07K14/59 ,  C07K14/505

CPC分类号： C07K14/59 ,  C07K14/505 ,  C07K14/555 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/35

摘要： A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.

公开(公告)号：US20150126445A1

公开(公告)日：2015-05-07

申请号：US14566681

申请日：2014-12-10

申请人： OPKO BIOLOGICS LTD.

发明人： FUAD FARES ,  UDI EYAL FIMA

IPC分类号： C07K14/505 ,  C07K14/59

CPC分类号： C07K14/505 ,  C07K14/555 ,  C07K14/59 ,  C07K14/61 ,  C07K2319/00 ,  C07K2319/31

摘要： A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical compositions comprising the non-human polypeptides and polynucleotides of the invention and methods of using both human and non-human polypeptides and polynucleotides are also disclosed.

公开(公告)号：US20150079063A1

公开(公告)日：2015-03-19

申请号：US14274061

申请日：2014-05-09

申请人： OPKO Biologics Ltd.

发明人： Udi Eyal FIMA ,  Gili Hart

IPC分类号： C12N9/96 ,  C07K14/59 ,  C12N9/64

CPC分类号： C12N9/96 ,  A61K38/00 ,  C07K14/505 ,  C07K14/59 ,  C07K14/745 ,  C07K2319/31 ,  C12N9/6437 ,  C12N9/644

摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.

摘要翻译： 公开了包含至少一个连接到羧基末端而不是凝固因子的氨基末端的绒毛膜促性腺激素的羧基末端肽（CTP）的多肽和编码其的多核苷酸。 还公开了包含本发明的多肽和多核苷酸的药物组合物及其使用和生产方法。

公开(公告)号：US20150072924A1

公开(公告)日：2015-03-12

申请号：US14395441

申请日：2013-04-17

申请人： OPKO Biologics Ltd.

发明人： Udi Eyal Fima ,  Oren Hershkovitz

IPC分类号： C07K14/575 ,  C07K14/59

CPC分类号： C07K14/575 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/24 ,  A61K38/26 ,  C07K14/59 ,  C07K14/605 ,  C07K2319/75

摘要： This invention is directed to a chorionic gonadotrophin carboxy terminal peptide (CTP) modified dual GLP-1/Glucagon receptor agonist, and methods of producing and using the same. In one embodiment, the present invention provides a CTP-modified polypeptide comprising a dual GLP-1/Glucagon receptor agonist and at least one chorionic gonadotrophin carboxy terminal peptide (CTP) attached to the amino terminus or carboxy terminus of said agonist.

摘要翻译： 本发明涉及绒毛膜促性腺激素羧基末端肽（CTP）修饰的双重GLP-1 /胰高血糖素受体激动剂及其制备和使用方法。 在一个实施方案中，本发明提供了包含双GLP-1 /胰高血糖素受体激动剂和连接于所述激动剂的氨基末端或羧基末端的至少一个绒毛膜促性腺激素羧基末端肽（CTP）的CTP-修饰的多肽。

公开(公告)号：US20220241380A1

公开(公告)日：2022-08-04

申请号：US17549017

申请日：2021-12-13

申请人： OPKO BIOLOGICS LTD.

发明人： Fuad FARES ,  Udi Eyal FIMA

IPC分类号： A61K38/27 ,  C07K14/61 ,  C07K14/59 ,  A61K38/24 ,  C07K14/555 ,  C07K14/505 ,  A61K47/02 ,  A61K47/12 ,  G01N33/74

摘要： CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.