A performance footwear, apparel or medical accessory product for hot, cold, and all-weather conditions, the performance footwear, apparel or medical accessory product comprised of a series of material layers having: a first layer of a breathable, moisture transfer, antimicrobial inner lining, fabric or nonwoven material or a combination of fabric or nonwoven material; a second layer comprising a breathable, moisture transfer, absorbent, antimicrobial, mechanically bonded, antimicrobial, nonwoven material comprised of shaped, channeled, grooved and lobed synthetic polymer fibers, antimicrobial silver polymer fibers and natural and synthetic, thermal and cooling fibers wherein the fiber combinations naturally provide adjustable thermal regulation; and a third exterior layer comprised of a breathable, antimicrobial woven fabric, knitted fabric, spacer fabric, nonwoven material, leather material or a combination thereof.