- 专利标题: Genetically stable live attenuated respiratory syncytial virus vaccine and its production
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申请号: US16425725申请日: 2019-05-29
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公开(公告)号: US10980872B2公开(公告)日: 2021-04-20
- 发明人: Peter L. Collins , Cindy L. Luongo , Ursula J. Buchholz , Brian R. Murphy
- 申请人: The United States of America, as represented by the Secretary, Department of Health and Human Services
- 申请人地址: US MD Bethesda
- 专利权人: The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人: The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址: US MD Bethesda
- 代理机构: Klarquist Sparkman, LLP
- 主分类号: A61K39/155
- IPC分类号: A61K39/155 ; A61K39/12 ; C07K14/005 ; C12N7/00 ; A61K39/00
摘要:
Provided herein are recombinant respiratory syncytial viruses that contain mutations that make the disclosed viruses attractive vaccine candidates. The viruses disclosed contain attenuating mutations designed to have increased genetic and phenotypic stability. Desired combinations of these mutations can be made to achieve desired levels of attenuation. Exemplary vaccine candidates are described. Also provided are polynucleotides capable of encoding the described viruses, as wells as methods for producing the viruses and methods of use.
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