Examples described herein relate to efficient memory access. An example is a system includes a programmable device, and a memory. The programmable device is coupled to the host and receives the read/write requests and the addresses associated therewith. The programmable device interleaves the read/write requests across multiple communication channels based on a subset of bits within each address. The memory receives the read/write requests from the programmable device. The memory stores contents associated with the addresses for write requests and returns contents associated with the addresses for a read request to the programmable device. The programmable device returns the received contents to the host for processing.