A processing system includes a processor and a VM-to-VM communication accelerator circuit comprising a first interface device to support direct memory access (DMA) data transfers by the first VM, a register to store a reference to a primary physical function (PF) associated with the first interface device, wherein the first primary PF is associated with an access control table (ACT) specifying an access permission for the first VM with respect to a second VM, and a direct memory access (DMA) descriptor processing circuit to process, using a working queue associated with the first primary PF, a DMA descriptor referencing a request for a DMA data transfer between the first VM and the second VM, and execute, using the first interface device, the DMA data transfer based on the access permission.