Invention Grant
- Patent Title: PARG inhibitory compounds
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Application No.: US16662997Application Date: 2019-10-24
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Publication No.: US10995073B2Publication Date: 2021-05-04
- Inventor: Alison E. McGonagle , Allan M. Jordan , Bodhan Waszkowycz , Colin P. Hutton , Ian D. Waddell , James R. Hitchin , Kate M. Smith , Niall M. Hamilton
- Applicant: CANCER RESEARCH TECHNOLOGY LIMITED
- Applicant Address: GB London
- Assignee: CANCER RESEARCH TECHNOLOGY LIMITED
- Current Assignee: CANCER RESEARCH TECHNOLOGY LIMITED
- Current Assignee Address: GB London
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky & Popeo, P.C.
- Priority: GB1422771 20141219
- Main IPC: C07D235/26
- IPC: C07D235/26 ; C07D403/04 ; C07D413/04 ; A61K31/4184 ; C07D413/14 ; C07D401/06 ; C07D403/06 ; C07D405/04 ; C07D405/06 ; C07D409/04 ; C07D413/06 ; C07D417/04 ; C07D417/14 ; C07D417/06 ; A61P35/00 ; C07D307/85
Abstract:
The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
Public/Granted literature
- US20200165208A1 PARG INHIBITORY COMPOUNDS Public/Granted day:2020-05-28
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