- 专利标题： Pyrimidinone derivatives as SHP2 antagonists
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申请号： US16843735申请日： 2020-04-08
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公开(公告)号： US11001561B2公开(公告)日： 2021-05-11
- 发明人: Catherine Jorand-Lebrun , Roch Boivin , Theresa Johnson , Yanping Wang , Yufang Xiao , Xiaoling Chen , Nina Linde , Doreen Musch , Deepak Kumar
- 申请人： MERCK PATENT GMBH
- 申请人地址： DE Darmstadt
- 专利权人： MERCK PATENT GMBH
- 当前专利权人： MERCK PATENT GMBH
- 当前专利权人地址： DE Darmstadt
- 代理机构： EMD Serono Research and Development Institute
- 代理商 Kathryn M. Bishop
- 优先权： EP19167897 20190408
- 主分类号： C07D239/36
- IPC分类号： C07D239/36 ; C07D239/42 ; C07D401/04 ; C07D401/14 ; C07D403/04 ; C07D471/10 ; C07D487/10 ; C07D491/052 ; C07D491/107 ; C07D491/20 ; A61P35/00
摘要：
The invention relates to pyrimidinone derivatives of the general Formula I, or a pharmaceutically acceptable salt thereof, and the use of the compounds of the present invention for the treatment of hyperproliferative diseases and disorders in mammals, especially humans, and pharmaceutical compositions containing such compound.
公开/授权文献
- US20200317622A1 PYRIMIDINONE DERIVATIVES AS SHP2 ANTAGONISTS 公开/授权日：2020-10-08
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