An adhesive therapeutic cover comprises at least one lift device and a single sheet of at least a two-ply material that includes a cover material with an adhesive on a bottom surface and a backing layer. The cover material defines at least one opening therethrough or at least one opening area which is removable after application of the cover material to a patient to form an opening through the cover material. The at least one lift device comprises a connector adhered or adherable to the cover material in alignment with the opening or opening area. The connector can be connected to a pressurized source of a flowable lifting agent, to urge the flowable lifting agent through the connector and the opening to separate the cover material from patient skin. Sensors can be provided to monitor and/or control the flow of lifting agent through the lifting device during removal of the cover from the patient.