Invention Grant
- Patent Title: Glucosylceramide synthase inhibitors
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Application No.: US15490385Application Date: 2017-04-18
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Publication No.: US11008316B2Publication Date: 2021-05-18
- Inventor: Elyse Bourque , Mario A. Cabrera-Salazar , Cassandra Celatka , Seng H. Cheng , Bradford Hirth , Andrew Good , Katherine Jancsics , John Marshall , Markus Metz , Ronald K. Scheule , Renato Skerlj , Yibin Xiang , Zhong Zhao , John Leonard , Thomas Natoli , Elina Makino , Herve Husson , Oxana Beskrovnaya
- Applicant: Genzyme Corporation
- Applicant Address: US MA Cambridge
- Assignee: Genzyme Corporation
- Current Assignee: Genzyme Corporation
- Current Assignee Address: US MA Cambridge
- Agency: Hoxie & Associates LLC
- Main IPC: C07D453/02
- IPC: C07D453/02 ; C07D471/08 ; A61K31/439 ; A61K31/496 ; A61K31/497 ; A61K31/506 ; A61K31/5377 ; A61K31/55 ; A61K31/551 ; A61K45/06
Abstract:
The invention relates to inhibitors of glucosylceramide synthase (GCS), such as Compound of Formula I, shown below, as defined herein, useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
Public/Granted literature
- US20180065957A1 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS Public/Granted day:2018-03-08
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