专利检索 ap:("Genzyme Corporation") AND inv:"Zhong Zhao" 第 1 页

1.

发明申请
NAMPT Inhibitors for Cancer Therapy 审中-公开

公开(公告)号：US20180312525A1

公开(公告)日：2018-11-01

申请号：US16026901

申请日：2018-07-03

申请人： Genzyme Corporation

发明人： Paul Mason , Kara Carter , Alexandra Joseph , Yiding Hu , Jill Gregory , Zhong Zhao , Christopher Yee , Mohamud Mohamud , Yibin Xiang , Sanjay Danthi , Yinyin Huang , Andrew Papoulis

IPC分类号： C07D498/10 , G01N33/60 , G01N33/50 , C07D491/107 , C07D491/20 , C12N5/0781

CPC分类号： C07D498/10 , C07D491/107 , C07D491/20 , C12N5/0635 , G01N33/5008 , G01N33/60

摘要： The invention features compounds of Formula (I), Formula (I)-A and Formula (I)-B as disclosed herein, as well as methods of synthesis, therapy, diagnostics, and assays.

2.

发明授权
Glucosylceramide synthase inhibitors 有权

公开(公告)号：US11008316B2

公开(公告)日：2021-05-18

申请号：US15490385

申请日：2017-04-18

申请人： Genzyme Corporation

发明人： Elyse Bourque , Mario A. Cabrera-Salazar , Cassandra Celatka , Seng H. Cheng , Bradford Hirth , Andrew Good , Katherine Jancsics , John Marshall , Markus Metz , Ronald K. Scheule , Renato Skerlj , Yibin Xiang , Zhong Zhao , John Leonard , Thomas Natoli , Elina Makino , Herve Husson , Oxana Beskrovnaya

IPC分类号： C07D453/02 , C07D471/08 , A61K31/439 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06

摘要： The invention relates to inhibitors of glucosylceramide synthase (GCS), such as Compound of Formula I, shown below, as defined herein, useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

3.

发明授权
NAMPT inhibitors and methods 有权

公开(公告)号：US10017523B2

公开(公告)日：2018-07-10

申请号：US15312482

申请日：2015-05-22

申请人： Genzyme Corporation

发明人： Paul Mason , Kara Carter , Alexandra Joseph , Yiding Hu , Jill Gregory , Zhong Zhao , Christopher Yee , Mohamud Mohamud , Yibin Xiang , Sanjay Danthi , Yinyin Huang , Andrew Papoulis

IPC分类号： C07D498/10 , C07D491/107 , C07D491/20 , C12N5/0781 , G01N33/50 , G01N33/60

CPC分类号： C07D498/10 , C07D491/107 , C07D491/20 , C12N5/0635 , G01N33/5008 , G01N33/60

摘要： The invention features compounds of Formula (I), Formula (I)-A and Formula (I)-B as disclosed herein, as well as methods of synthesis, therapy, diagnostics, and assays.

4.

发明授权
Glucosylceramide synthase inhibitors 有权

公开(公告)号：US12060349B2

公开(公告)日：2024-08-13

申请号：US17230385

申请日：2021-04-14

申请人： Genzyme Corporation

发明人： Elyse Bourque , Mario A. Cabrera-Salazar , Cassandra Celatka , Seng H. Cheng , Bradford Hirth , Andrew Good , Katherine Jancsics , John Marshall , Markus Metz , Ronald K. Scheule , Renato Skerlj , Yibin Xiang , Zhong Zhao , John Leonard , Thomas Natoli , Elina Makino , Herve Husson , Oxana Beskrovnaya

IPC分类号： C07D453/02 , A61K31/439 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D471/08

CPC分类号： C07D453/02 , A61K31/439 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D471/08

摘要： The invention relates to inhibitors of glucosylceramide synthase (GCS) of the Formula I: represented by the following structural formula

or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein, useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

5.

发明申请
NAMPT Inhibitors and Methods 有权

公开(公告)号：US20170107231A1

公开(公告)日：2017-04-20

申请号：US15312482

申请日：2015-05-22

申请人： Genzyme Corporation

发明人： Paul Mason , Kara Carter , Alexandra Joseph , Yiding Hu , Jill Gregory , Zhong Zhao , Christopher Yee , Mohamud Mohamud , Yibin Xiang , Sanjay Danthi , Yinyin Huang , Andrew Papoulis

IPC分类号： C07D498/10 , G01N33/50 , C12N5/0781 , C07D491/107 , G01N33/60

CPC分类号： C07D498/10 , C07D491/107 , C07D491/20 , C12N5/0635 , G01N33/5008 , G01N33/60

摘要： The invention features compounds of Formula (I), Formula (I)-A and Formula (I)-B as disclosed herein, as well as methods of synthesis, therapy, diagnostics, and assays.

6.

发明申请
GLUCOSYLCERAMIDE SYNTHASE INHIBITORS 审中-公开
标题翻译： GLUCOSYLCERAMIDE SYNTHASE抑制剂

公开(公告)号：US20150210681A1

公开(公告)日：2015-07-30

申请号：US14427275

申请日：2013-09-10

申请人： GENZYME CORPORATION

发明人： Elyse Bourque , Mario A. Cabrera-Salazar , Cassandra Celatka , Seng H. Cheng , Bradford Hirth , Andrew Good , Katherine Jancsics , John Marshall , Markus Metz , Ronald K. Scheule , Renato Skerlj , Yibin Xiang , Zhong Zhao , John Leonard , Thomas Natoli , Elina Makino , Herve Husson , Oxana Beskrovnaya

IPC分类号： C07D453/02 , C07D471/08 , A61K31/55 , A61K45/06 , A61K31/506 , A61K31/497 , A61K31/439 , A61K31/5377 , A61K31/496 , A61K31/551

CPC分类号： C07D453/02 , A61K31/439 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D471/08

摘要： The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

摘要翻译： 本发明涉及可用于单独或与酶替代疗法，囊性疾病和癌症治疗组合治疗代谢性疾病如溶酶体贮积病的葡萄糖神经酰胺合成酶（GCS）抑制剂。