- Patent Title: Trifunctional T cell-antigen coupler and methods and uses thereof
-
Application No.: US15929510Application Date: 2020-05-06
-
Publication No.: US11008376B2Publication Date: 2021-05-18
- Inventor: Jonathan Bramson , Christopher W. Helsen , Galina Denisova , Rajanish Giri , Kenneth Anthony Mwawasi
- Applicant: McMaster University
- Applicant Address: CA Hamilton
- Assignee: McMaster University
- Current Assignee: McMaster University
- Current Assignee Address: CA Hamilton
- Agency: Goodwin Procter LLP
- Main IPC: C07K14/73
- IPC: C07K14/73 ; C07K16/28 ; A61K35/17 ; C07K14/725 ; C07K16/32
Abstract:
A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
Public/Granted literature
- US20200270330A1 TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF Public/Granted day:2020-08-27
Information query
