公开(公告)号：US20230265207A1

公开(公告)日：2023-08-24

申请号：US18188318

申请日：2023-03-22

Applicant: McMaster University

Inventor： Christopher W. Helsen ,  Jonathan Bramson ,  Anna Dvorkin-Gheva ,  Galina F. Denisova ,  Ksenia Bezverbnaya ,  Kenneth Anthony Mwawasi

IPC: C07K16/30 ,  A61P35/00 ,  A61K9/00 ,  A61K38/00 ,  A61K39/385 ,  C07K14/525 ,  C07K14/725 ,  C07K14/73 ,  C07K14/705 ,  C07K16/28

CPC classification number: C07K16/3061 ,  A61P35/00 ,  A61K9/0019 ,  A61K38/00 ,  A61K39/385 ,  C07K14/525 ,  C07K14/7051 ,  C07K14/70514 ,  C07K14/70517 ,  C07K16/2809

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

公开(公告)号：US11643472B2

公开(公告)日：2023-05-09

申请号：US16753577

申请日：2018-10-12

Applicant: McMaster University

Inventor： Christopher W. Helsen ,  Jonathan Bramson ,  Anna Dvorkin-Gheva ,  Galina F. Denisova ,  Ksenia Bezverbnaya ,  Kenneth Anthony Mwawasi

IPC: C07K16/30 ,  A61P35/00 ,  A61K9/00 ,  A61K38/00 ,  C07K14/725 ,  C07K14/73 ,  C07K16/28 ,  A61K39/385 ,  C07K14/525 ,  C07K14/705

CPC classification number: C07K16/3061 ,  A61K9/0019 ,  A61K38/00 ,  A61K39/385 ,  A61P35/00 ,  C07K14/525 ,  C07K14/7051 ,  C07K14/70514 ,  C07K14/70517 ,  C07K16/2809

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

公开(公告)号：US20210276981A1

公开(公告)日：2021-09-09

申请号：US17249332

申请日：2021-02-26

Applicant: McMaster University

Inventor： Anthony Rullo ,  Jonathan Bramson ,  Yonghong Wan ,  Benjamin Lake ,  Nickolas Semiuck

IPC: C07D403/12 ,  C07D493/10 ,  C07D233/90

Abstract: The present application relates to compounds of Formula I comprising an antibody binding domain (ABD) comprising a hapten that binds to an antibody in a subject, the antibody comprising a hapten binding site, an antibody labelling domain (ALD) comprising a functional group that forms a covalent bond with an amino acid in the antibody that is proximal to the hapten binding site and the formation of the covalent bond results in elimination of the ABD and either a target binding domain (TBD) or a detection moiety domain (DMD), each domain being optionally connected with independently selected linkers. The present application also includes methods and uses of the compounds, for example, for immune recognition of target cells by recruited labelled antibodies. ABD−(L1)n-ALD-(L2)m-R

公开(公告)号：US11970545B2

公开(公告)日：2024-04-30

申请号：US18188318

申请日：2023-03-22

Applicant: McMaster University

Inventor： Christopher W. Helsen ,  Jonathan Bramson ,  Anna Dvorkin-Gheva ,  Galina F. Denisova ,  Ksenia Bezverbnaya ,  Kenneth Anthony Mwawasi

IPC: C07K16/30 ,  A61K9/00 ,  A61K38/00 ,  A61K39/385 ,  A61P35/00 ,  C07K14/525 ,  C07K14/705 ,  C07K14/725 ,  C07K14/73 ,  C07K16/28

CPC classification number: C07K16/3061 ,  A61K9/0019 ,  A61K38/00 ,  A61K39/385 ,  A61P35/00 ,  C07K14/525 ,  C07K14/7051 ,  C07K14/70514 ,  C07K14/70517 ,  C07K16/2809

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

公开(公告)号：US20230212258A1

公开(公告)日：2023-07-06

申请号：US18188312

申请日：2023-03-22

Applicant: McMaster University

Inventor： Jonathan Bramson ,  Christopher W. Helsen ,  Galina Denisova ,  Rajanish Giri ,  Kenneth Anthony Mwawasi

IPC: C07K14/73 ,  C07K16/32 ,  C07K16/28 ,  A61P35/00 ,  A61K35/17

CPC classification number: C07K14/70514 ,  A61K35/17 ,  A61P35/00 ,  C07K16/32 ,  C07K16/2809 ,  C07K16/2878 ,  A61K2039/5156 ,  C07K2319/03

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders anti -gen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

公开(公告)号：US11198737B2

公开(公告)日：2021-12-14

申请号：US17301884

申请日：2021-04-16

Applicant: McMaster University

Inventor： Christopher W. Helsen ,  Jonathan Bramson ,  Anna Dvorkin-Gheva ,  Galina F. Denisova ,  Ksenia Bezverbnaya ,  Kenneth Anthony Mwawasi

IPC: C07K16/30 ,  A61P35/00 ,  A61K9/00 ,  A61K38/00 ,  C07K14/525 ,  C07K14/725 ,  C07K14/73 ,  C07K14/705 ,  C07K16/28 ,  A61K39/385

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y177 mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

公开(公告)号：US20220348936A1

公开(公告)日：2022-11-03

申请号：US17753119

申请日：2020-09-16

Applicant: McMaster University

Inventor： Jonathan Bramson ,  Phillip Marvyn

IPC: C12N15/62 ,  C07K14/705 ,  C07K14/715 ,  C12N5/0783

Abstract: Described herein is a chimeric costimulatory receptor (CCR) molecule having an extracellular domain of a Tumor Necrosis Factor Superfamily member, a transmembrane domain and a cytosolic costimulatory signaling domain from a Tumor Necrosis Factor Receptor Superfamily member is provided. Also provided are pharmaceutical compositions having a T cell expressing CCR and methods and uses of such T cells to treat cancers.

公开(公告)号：US11008376B2

公开(公告)日：2021-05-18

申请号：US15929510

申请日：2020-05-06

Applicant: McMaster University

Inventor： Jonathan Bramson ,  Christopher W. Helsen ,  Galina Denisova ,  Rajanish Giri ,  Kenneth Anthony Mwawasi

IPC: C07K14/73 ,  C07K16/28 ,  A61K35/17 ,  C07K14/725 ,  C07K16/32

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

公开(公告)号：US20240109870A1

公开(公告)日：2024-04-04

申请号：US18383687

申请日：2023-10-25

Applicant: McMaster University

Inventor： Anthony Rullo ,  Jonathan Bramson ,  Yonghong Wan ,  Benjamin Lake ,  Nickolas Serniuck

IPC: C07D403/12 ,  C07D233/90 ,  C07D493/10

CPC classification number: C07D403/12 ,  C07D233/90 ,  C07D493/10 ,  C07K16/44

Abstract: The present application relates to compounds of Formula I comprising an antibody binding domain (ABD) comprising a hapten that binds to an antibody in a subject, the antibody comprising a hapten binding site, an antibody labelling domain (ALD) comprising a functional group that forms a covalent bond with an amino acid in the antibody that is proximal to the hapten binding site and the formation of the covalent bond results in elimination of the ABD and either a target binding domain (TBD) or a detection moiety domain (DMD), each domain being optionally connected with independently selected linkers. The present application also includes methods and uses of the compounds, for example, for immune recognition of target cells by recruited labelled antibodies.


ABD-(L1)n-ALD-(L2)m-R  I

公开(公告)号：US11001621B1

公开(公告)日：2021-05-11

申请号：US17248174

申请日：2021-01-12

Applicant: McMaster University

Inventor： Jonathan Bramson ,  Christopher W. Helsen ,  Galina Denisova ,  Rajanish Giri ,  Kenneth Anthony Mwawasi

IPC: C07K14/73 ,  C07K16/28 ,  A61K35/17 ,  C07K14/725 ,  C07K16/32

Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.