Invention Grant
- Patent Title: Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators
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Application No.: US16496279Application Date: 2018-03-20
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Publication No.: US11014927B2Publication Date: 2021-05-25
- Inventor: Anna Ericsson , Neal Green , Gary Gustafson , Bingsong Han , David R. Lancia, Jr. , Lorna Mitchell , David Richard , Tatiana Shelekhin , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng
- Applicant: FORMA Therapeutics, Inc.
- Applicant Address: US MA Watertown
- Assignee: FORMA Therapeutics, Inc.
- Current Assignee: FORMA Therapeutics, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Barnes & Thornburg LLP
- International Application: PCT/US2018/023405 WO 20180320
- International Announcement: WO2018/175474 WO 20180927
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D519/00 ; A61P7/00 ; A61K9/00 ; A61K31/407
Abstract:
The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds of formula (I) useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.
Public/Granted literature
- US20200069643A1 PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE (PKR) ACTIVATORS Public/Granted day:2020-03-05
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