公开(公告)号：US11649242B2

公开(公告)日：2023-05-16

申请号：US17239364

申请日：2021-04-23

申请人： FORMA Therapeutics, Inc.

发明人： Anna Ericsson ,  Neal Green ,  Gary Gustafson ,  Bingsong Han ,  David R. Lancia, Jr. ,  Lorna Mitchell ,  David Richard ,  Tatiana Shelekhin ,  Chase C. Smith ,  Zhongguo Wang ,  Xiaozhang Zheng

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61P7/00 ,  A61K9/00 ,  A61K31/407

CPC分类号： C07D487/04 ,  A61K9/0053 ,  A61K31/407 ,  A61P7/00 ,  C07D519/00

摘要： The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

公开(公告)号：US11014927B2

公开(公告)日：2021-05-25

申请号：US16496279

申请日：2018-03-20

申请人： FORMA Therapeutics, Inc.

发明人： Anna Ericsson ,  Neal Green ,  Gary Gustafson ,  Bingsong Han ,  David R. Lancia, Jr. ,  Lorna Mitchell ,  David Richard ,  Tatiana Shelekhin ,  Chase C. Smith ,  Zhongguo Wang ,  Xiaozhang Zheng

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61P7/00 ,  A61K9/00 ,  A61K31/407

摘要： The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds of formula (I) useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.