Invention Grant
- Patent Title: Methods for increasing efficiency of nuclease-induced homology-directed repair
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Application No.: US15516310Application Date: 2015-10-01
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Publication No.: US11021718B2Publication Date: 2021-06-01
- Inventor: J. Keith Joung , Benjamin Kleinstiver , Jason Michael Gehrke , Shengdar Tsai , James Angstman , Rebecca Tayler Cottman
- Applicant: The General Hospital Corporation
- Applicant Address: US MA Boston
- Assignee: The General Hospital Corporation
- Current Assignee: The General Hospital Corporation
- Current Assignee Address: US MA Boston
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2015/053417 WO 20151001
- International Announcement: WO2016/054326 WO 20160407
- Main IPC: C12N15/90
- IPC: C12N15/90 ; C12N9/22 ; C12N15/11 ; C12N15/10 ; C12N15/63
Abstract:
The present invention relates to methods to improve the absolute rate of homology-directed repair (HDR) and/or to improve the relative rate of HDR compared with non-homologous end joining (NHEJ).
Public/Granted literature
- US20180230494A1 METHODS FOR INCREASING EFFICIENCY OF NUCLEASE-INDUCED HOMOLOGY-DIRECTED REPAIR Public/Granted day:2018-08-16
Information query
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