Methods, apparatus, systems and articles of manufacture are disclosed for anomaly detection and recovery. An apparatus to isolate a first controller in an autonomous vehicle includes a first controller to control a reference signal of the autonomous vehicle via a communication bus, a second controller to control the reference signal of the autonomous vehicle when the first controller is compromised, and a message neutralizer to neutralize messages transmitted by the first controller when the first controller is compromised, the neutralized messages to cause the first controller to become isolated from the communication bus.