Invention Grant
- Patent Title: Immortalized sweat gland myoepithelial cell
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Application No.: US16626052Application Date: 2018-08-07
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Publication No.: US11060061B2Publication Date: 2021-07-13
- Inventor: Tomohisa Hayakawa , Ryuichiro Kurata , Fumitaka Fujita , Fumihiro Okada , Kiyotoshi Sekiguchi
- Applicant: MANDOM CORPORATION , OSAKA UNIVERSITY
- Applicant Address: JP Osaka; JP Suita
- Assignee: MANDOM CORPORATION,OSAKA UNIVERSITY
- Current Assignee: MANDOM CORPORATION,OSAKA UNIVERSITY
- Current Assignee Address: JP Osaka; JP Suita
- Agency: Westerman, Hattori, Daniels and Adrian, LLP
- Priority: JPJP2017-154503 20170809
- International Application: PCT/JP2018/029594 WO 20180807
- International Announcement: WO2019/031500 WO 20190214
- Main IPC: C12N5/077
- IPC: C12N5/077 ; C12N15/85 ; C12N15/86

Abstract:
An immortalized sweat gland myoepithelial cell which expresses α-SMA and pan-cytokeratin and has a sphere forming ability after subculture at least 5 times. A method for producing immortalized sweat gland myoepithelial said method comprising: while culturing a cell structure, wherein sweat gland myoepithelial cells are exposed on a surface, in a state of being suspended in a medium, transferring an immortalizing gene into the cells; and then culturing the transgenic structure thus obtained in a state of being suspended in the medium to thereby obtain immortalized sweat gland myoepithelial cells.
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