公开(公告)号：US20210361549A1

公开(公告)日：2021-11-25

申请号：US16641775

申请日：2019-03-18

Applicant: MANDOM CORPORATION ,  OSAKA UNIVERSITY

Inventor： Kie Nakashima ,  Ryuichiro Kurata ,  Fumitaka Fujita ,  Fumihiro Okada

IPC: A61K8/365 ,  A61K8/37 ,  A61K8/60 ,  A61Q15/00

Abstract: Provided is an antiperspirant which serves to control secretion of sweat secreted from sweat glands and is capable of doing so by acting on sweat glands without closing sweat pores, the antiperspirant containing, as an active ingredient to control secretion of sweat secreted from sweat glands, at least one type of pentacyclic compound selected from the group consisting of compounds represented by formula (I): and derivatives thereof, and compounds represented by formula (VII): and derivatives thereof.

公开(公告)号：US20210003546A1

公开(公告)日：2021-01-07

申请号：US16977918

申请日：2019-03-08

Applicant: MANDOM CORPORATION ,  OSAKA UNIVERSITY ,  NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION

Inventor： Manami Toriyama ,  Fumitaka Fujita ,  Fumihiro Okada ,  Ken Ishii

IPC: G01N33/483 ,  G01N33/569

Abstract: Provided is a method whereby an objective indicator of an immune-related disease can be rapidly and easily detected, the method comprising detecting, as an indicator of an immune-related disease, a difference in the result of observing a primary cilium of an immune-related cell between a subject specimen and a normal specimen.

公开(公告)号：US20230057230A1

公开(公告)日：2023-02-23

申请号：US17789867

申请日：2021-01-07

Applicant: MANDOM CORPORATION ,  OSAKA UNIVERSITY ,  PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY

Inventor： Manami Toriyama ,  Fumitaka Fujita ,  Fumihiro Okada ,  Akimichi Morita ,  Motoki Nakamura

IPC: G01N33/574

Abstract: The present invention provides a novel method for detecting an indicator of T cell lymphoma. The method for detecting an indicator of T cell lymphoma includes the step of detecting acetylated tubulin in a T cell that has been collected from a subject.

公开(公告)号：US11060061B2

公开(公告)日：2021-07-13

申请号：US16626052

申请日：2018-08-07

Applicant: MANDOM CORPORATION ,  OSAKA UNIVERSITY

Inventor： Tomohisa Hayakawa ,  Ryuichiro Kurata ,  Fumitaka Fujita ,  Fumihiro Okada ,  Kiyotoshi Sekiguchi

IPC: C12N5/077 ,  C12N15/85 ,  C12N15/86

Abstract: An immortalized sweat gland myoepithelial cell which expresses α-SMA and pan-cytokeratin and has a sphere forming ability after subculture at least 5 times. A method for producing immortalized sweat gland myoepithelial said method comprising: while culturing a cell structure, wherein sweat gland myoepithelial cells are exposed on a surface, in a state of being suspended in a medium, transferring an immortalizing gene into the cells; and then culturing the transgenic structure thus obtained in a state of being suspended in the medium to thereby obtain immortalized sweat gland myoepithelial cells.