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公开(公告)号:US11464720B2
公开(公告)日:2022-10-11
申请号:US16495663
申请日:2018-03-13
Applicant: MANDOM CORPORATION , TAKASAGO INTERNATIONAL CORPORATION
Inventor: Masayuki Takaishi , Fumitaka Fujita , Hironori Shimizu , Shu Sakuyama , Kenya Ishida , Kenji Maruyama
Abstract: This TRPA1 activity inhibitor contains a compound represented by formula (I) wherein R1, R2, R3 and R4 each independently represent a hydrogen atom or a methyl group, and R5, R6, R7 and R8 each independently represent a hydrogen atom, a methyl group or —O—R9—OH (in the formula, R9 represents an alkylene group optionally having a substituent group), provided that at least one group of R5, R6, R7 and R8 is —O—R9—OH.
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公开(公告)号:US09737467B2
公开(公告)日:2017-08-22
申请号:US15346698
申请日:2016-11-08
Applicant: MANDOM CORPORATION
Inventor: Takeshi Hara , Hironori Shimizu
CPC classification number: A61K8/29 , A61K8/0241 , A61K8/0279 , A61K8/046 , A61K8/19 , A61K2800/412 , A61K2800/621 , A61K2800/651 , A61Q15/00
Abstract: The present invention provides a body odor suppressing agent that contains activated carbon and that has excellent body odor suppressing effects, causes no black soiling on an object to be coated, and has excellent practical aptitude. The present invention also provides a body odor suppressing agent having an excellent feeling of use when the agent is applied to the skin. The present invention further provides a body odor suppressing agent capable of preventing nozzles from clogging when the agent is packed into a spray container and used. The body odor suppressing agent of the present invention includes a titanium oxide-coated activated carbon including an activated carbon having an average particle diameter of 15 to 50 μm and a titanium oxide present over the surface of the activated carbon.
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公开(公告)号:US11085916B2
公开(公告)日:2021-08-10
申请号:US16085755
申请日:2017-07-18
Applicant: MANDOM CORPORATION , OSAKA UNIVERSITY
Inventor: Kie Nakashima , Ryuichiro Kurata , Fumitaka Fujita , Kiyotoshi Sekiguchi , Atsushi Tanemura , Hiroyuki Murota , Ichiro Katayama
Abstract: A method for observing the dynamics of sweat glands and a method for evaluating a substance of interest, which are useful for development of a preparation for external application, such as a cosmetic. In each of the methods, an observation sample is used, which is prepared by staining all sweat glands, which are isolated alive, with a staining reagent, and then holding the all sweat glands on a support using at least one material selected from the group consisting of collagen, agarose, basement membrane matrix, poly-D-lysine and a membrane.
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公开(公告)号:US20200003756A1
公开(公告)日:2020-01-02
申请号:US16491681
申请日:2018-02-28
Applicant: MANDOM CORPORATION
Inventor: Shuta Ishizuka , Ryuichiro Kurata
Abstract: A method for observing a sebaceous gland, the method being useful for such applications as developing a cosmetic material or other external preparation, and including (I) a step for culturing, in a suspended state in a medium, a sebaceous gland structure in which the dermis and all or a portion of the subcutaneous tissue is removed from a skin tissue, and (II) a step for observing the cultured sebaceous gland structure obtained in step (I).
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公开(公告)号:US20170049672A1
公开(公告)日:2017-02-23
申请号:US15346698
申请日:2016-11-08
Applicant: MANDOM CORPORATION
Inventor: Takeshi Hara , Hironori Shimizu
CPC classification number: A61K8/29 , A61K8/0241 , A61K8/0279 , A61K8/046 , A61K8/19 , A61K2800/412 , A61K2800/621 , A61K2800/651 , A61Q15/00
Abstract: The present invention provides a body odor suppressing agent that contains activated carbon and that has excellent body odor suppressing effects, causes no black soiling on an object to be coated, and has excellent practical aptitude. The present invention also provides a body odor suppressing agent having an excellent feeling of use when the agent is applied to the skin. The present invention further provides a body odor suppressing agent capable of preventing nozzles from clogging when the agent is packed into a spray container and used. The body odor suppressing agent of the present invention includes a titanium oxide-coated activated carbon including an activated, carbon having an average particle diameter of 15 to 50 μm and a titanium oxide present over the surface of the activated carbon.
Abstract translation: 本发明提供一种含有活性炭的身体臭味抑制剂,具有优异的除臭效果,对被涂物没有黑色污渍,具有优异的实用性。 本发明还提供了当将药剂施用于皮肤时具有优异的使用感的身体臭味抑制剂。 本发明还提供一种防臭剂,其能够防止在将试剂装入喷雾容器并使用时堵塞喷嘴。 本发明的体臭抑制剂包括具有平均粒径为15〜50μm的活性碳,存在于活性炭表面的氧化钛的氧化钛被覆活性炭。
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公开(公告)号:US20210361549A1
公开(公告)日:2021-11-25
申请号:US16641775
申请日:2019-03-18
Applicant: MANDOM CORPORATION , OSAKA UNIVERSITY
Inventor: Kie Nakashima , Ryuichiro Kurata , Fumitaka Fujita , Fumihiro Okada
Abstract: Provided is an antiperspirant which serves to control secretion of sweat secreted from sweat glands and is capable of doing so by acting on sweat glands without closing sweat pores, the antiperspirant containing, as an active ingredient to control secretion of sweat secreted from sweat glands, at least one type of pentacyclic compound selected from the group consisting of compounds represented by formula (I): and derivatives thereof, and compounds represented by formula (VII): and derivatives thereof.
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公开(公告)号:US20210003546A1
公开(公告)日:2021-01-07
申请号:US16977918
申请日:2019-03-08
Applicant: MANDOM CORPORATION , OSAKA UNIVERSITY , NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION
Inventor: Manami Toriyama , Fumitaka Fujita , Fumihiro Okada , Ken Ishii
IPC: G01N33/483 , G01N33/569
Abstract: Provided is a method whereby an objective indicator of an immune-related disease can be rapidly and easily detected, the method comprising detecting, as an indicator of an immune-related disease, a difference in the result of observing a primary cilium of an immune-related cell between a subject specimen and a normal specimen.
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公开(公告)号:US20160166491A1
公开(公告)日:2016-06-16
申请号:US14904066
申请日:2015-02-20
Applicant: MANDOM CORPORATION
Inventor: Keiji Kasahara , Takeshi Hisahara
IPC: A61K8/73 , A61K8/26 , A61K8/27 , A61K8/365 , A61K8/34 , A61K8/31 , A61K8/35 , A61Q15/00 , A61K8/37
CPC classification number: A61K8/731 , A61K8/26 , A61K8/27 , A61K8/315 , A61K8/34 , A61K8/347 , A61K8/35 , A61K8/365 , A61K8/368 , A61K8/37 , A61K8/375 , A61K8/39 , A61K8/416 , A61Q15/00
Abstract: Provided are a deodorant composition that can dramatically improve the remaining performance of a bactericide on an application object after application and a deodorant product comprising the deodorant composition. The deodorant composition according to the present invention comprises ethanol, a bactericide, a hydrophobized hydroxyalkyl cellulose, and an ester compound having a molecular weight of 150 or more; and the deodorant product according to the present invention comprises a container and the deodorant composition filled in the container.
Abstract translation: 提供了一种除臭剂组合物,其可以显着地改善施用后的施用对象上的杀菌剂的剩余性能和包含除臭剂组合物的除臭剂产品。 根据本发明的除臭剂组合物包含乙醇,杀菌剂,疏水化羟烷基纤维素和分子量为150以上的酯化合物; 并且根据本发明的除臭产品包含容器和装在容器中的除臭剂组合物。
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公开(公告)号:US20200371090A1
公开(公告)日:2020-11-26
申请号:US16769719
申请日:2019-09-05
Applicant: MANDOM CORPORATION
Inventor: Shuta Ishizuka , Ryuichiro Kurata
Abstract: Provided is a method for observing a sebaceous gland, the method making it possible to observe dynamics of a sebaceous gland which dynamics are close to dynamics of a sebaceous gland in a living body. The method includes: an anchoring step of anchoring a sebaceous gland structure to a support so that a sebaceous gland that is included in the sebaceous gland structure and is to be observed and the support are not in biological contact with each other, the sebaceous gland structure being obtained by removing all or part of each of dermis and hypodermis from a skin tissue; and an observation step of observing the sebaceous gland structure obtained in the anchoring step.
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公开(公告)号:US20200022889A1
公开(公告)日:2020-01-23
申请号:US16495663
申请日:2018-03-13
Applicant: MANDOM CORPORATION , TAKASAGO INTERNATIONAL CORPORATION
Inventor: Masayuki Takaishi , Fumitaka Fujita , Hironori Shimizu , Shu Sakuyama , Kenya Ishida , Kenji Maruyama
Abstract: This TRPA1 activity inhibitor contains a compound represented by formula (I) wherein R1, R2, R3 and R4 each independently represent a hydrogen atom or a methyl group, and R5, R6, R7 and R8 each independently represent a hydrogen atom, a methyl group or —O—R9—OH (in the formula, R9 represents an alkylene group optionally having a substituent group), provided that at least one group of R5, R6, R7 and R8 is —O—R9—OH.
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