- 专利标题: Inhibitors of 17β-HSD1, 17β-HSD3 and 17β-HSD10
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申请号: US14007577申请日: 2012-03-26
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公开(公告)号: US11072632B2公开(公告)日: 2021-07-27
- 发明人: Donald Poirier , Jenny Roy , Rene Maltais
- 申请人: Donald Poirier , Jenny Roy , Rene Maltais
- 申请人地址: CA L 'Ancienne-Lorette; CA Saint-Jean-Chrysostome; CA Quebec
- 专利权人: Donald Poirier,Jenny Roy,Rene Maltais
- 当前专利权人: Donald Poirier,Jenny Roy,Rene Maltais
- 当前专利权人地址: CA L 'Ancienne-Lorette; CA Saint-Jean-Chrysostome; CA Quebec
- 代理机构: Parker Highlander PLLC
- 国际申请: PCT/CA2012/000316 WO 20120326
- 国际公布: WO2012/129673 WO 20121004
- 主分类号: C07J41/00
- IPC分类号: C07J41/00 ; A61K31/567 ; A61K31/58 ; A61K51/04 ; A61K31/566 ; A61K31/69 ; A61K31/675 ; C07J51/00 ; C07J1/00 ; A61K31/5685 ; A61K45/06 ; C07J43/00 ; C07J21/00 ; C07J31/00
摘要:
The present application discloses 17β hydroxy steroid dehydrogenase (17β HSD) type 1, 3, 10 inhibitors and use thereof (alone and in combination) in the treatment of cancer and other afflictions. 17β HSD1 inhibitors include estradiol derivatives with a nieta-carbamoylbenzyl substituent at C 16. 17β HSD3/HSD10 inhibitors include androsterone derivatives substituted at the C3 position with a sulfonamide piperazine. Also disclosed are compounds that are inhibitors of both 17β HSD1 and 17β HSD3 that have a spiro-morpholine substituent at C20.
公开/授权文献
- US20140088053A1 INHIBITORS OF 17Beta-HSD1, 17Beta-HSD3 AND 17Beta-HSD10 公开/授权日:2014-03-27