- 专利标题： 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof
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申请号： US15622568申请日： 2017-06-14
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公开(公告)号： US11078230B2公开(公告)日： 2021-08-03
- 发明人: Eric Anderson , Xiaofeng Liu , Andrea Decker
- 申请人： REATA PHARMACEUTICALS, INC.
- 申请人地址： US TX Irving
- 专利权人： REATA PHARMACEUTICALS, INC.
- 当前专利权人： REATA PHARMACEUTICALS, INC.
- 当前专利权人地址： US TX Irving
- 代理机构： Parker Highlander PLLC
- 主分类号： C07J63/00
- IPC分类号： C07J63/00 ; C07C255/47 ; A61K31/277
摘要：
The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7, 8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.
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