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公开(公告)号：US11091430B2
公开(公告)日：2021-08-17
申请号：US16786429
申请日：2020-02-10
发明人： Eric Anderson , Xin Jiang , Melean Visnick
IPC分类号： C07C255/47 , C07J63/00 , C07C275/34 , C07C271/24 , C07C275/26 , C07C311/09 , C07D261/08 , C07D307/20 , C07D487/08 , C07C311/07 , C07D209/56 , C07D211/44 , C07D231/12 , C07D295/195
摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
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公开(公告)号：US11192852B2
公开(公告)日：2021-12-07
申请号：US16701585
申请日：2019-12-03
发明人： Eric Anderson , Gary L. Bolton , Bradley Caprathe , Xin Jiang , Chitase Lee , William H. Roark , Melean Visnick
IPC分类号： C07C255/47 , C07D239/70 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D487/04 , C07D231/54
摘要： Disclosed herein are novel antioxidant inflammation modulators, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds and compositions thereof are also provided.
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3.发明申请公开(公告)号：US20190119202A1
公开(公告)日：2019-04-25
申请号：US16115028
申请日：2018-08-28
发明人： Eric Anderson , Xin Jiang , Melean Visnick
IPC分类号： C07C255/47 , C07D487/08 , C07D295/195 , C07D211/44 , C07D231/12 , C07C311/07 , C07D209/56 , C07J63/00 , C07D307/20 , C07D261/08 , C07C311/09 , C07C275/26 , C07C271/24
摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
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公开(公告)号：US09884809B2
公开(公告)日：2018-02-06
申请号：US14877974
申请日：2015-10-08
发明人： Eric Anderson , Gary L. Bolton , Bradley Caprathe , Xin Jiang , Chitase Lee , William H. Roark , Melean Visnick
IPC分类号： C07C255/47 , C07D231/54 , C07D239/70 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D487/04
CPC分类号： C07C255/47 , C07D231/54 , C07D239/70 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D487/04
摘要： Disclosed herein are novel antioxidant inflammation modulators, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds and compositions thereof are also provided.
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5.发明授权公开(公告)号：US09796668B2
公开(公告)日：2017-10-24
申请号：US14950557
申请日：2015-11-24
发明人： Eric Anderson , Gary L. Bolton , Deborah A. Ferguson , Xin Jiang , Robert M. Kral, Jr. , Patrick M. O'Brien , Melean Visnick
IPC分类号： A61K31/277 , C07C255/46 , C07D311/74 , C07D317/26 , C07D493/10 , C07F7/18 , C07J21/00 , C07J41/00 , C07J53/00 , C07J71/00
CPC分类号： C07C255/46 , C07C2601/16 , C07D311/74 , C07D317/26 , C07D493/10 , C07F7/1804 , C07J21/003 , C07J41/0055 , C07J41/0094 , C07J53/001 , C07J71/0005
摘要： This invention provides novel compounds comprising the following anti-inflammatory pharmacore: wherein X, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
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6.发明授权Aryl and arylalkyl substituted pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators 有权芳基和芳基烷基取代的吡唑基和嘧啶基三环烯酮作为抗氧化剂炎症调节剂公开(公告)号：US09464082B2
公开(公告)日：2016-10-11
申请号：US14604129
申请日：2015-01-23
发明人： Pamela Donner , Rolf Wagner , Jason Shanley , Howard Heyman , Allan Krueger , Hui-Ju Chen , Michael Rozema , David Grampovnik , Melean Visnick , Eric Anderson , Xin Jiang , Christopher F. Bender , Gary Louis Bolton , Bradley William Caprathe , Chitase Lee , William Howard Roark
IPC分类号： C07D231/54 , C07D239/70 , C07D239/72 , C07D401/04 , C07D403/04 , C07D417/04 , C07D471/04 , C07D413/04
CPC分类号： C07D471/04 , C07D231/54 , C07D239/70 , C07D239/72 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要： The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein R1, R2, R3, R4, R5, R6, m, n, X and Y are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation.
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7.发明申请ARYL AND ARYLALKYL SUBSTITUTED PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS 有权ARYL和ARYLALKYL取代的吡唑并吡啶并吡啶酮作为抗氧化剂的炎症调节剂公开(公告)号：US20150225397A1
公开(公告)日：2015-08-13
申请号：US14604129
申请日：2015-01-23
发明人： Pamela Donner , Rolf Wagner , Jason Shanley , Howard Heyman , Allan Krueger , Hui-Ju Chen , Michael Rozema , David Grampovnik , Melean Visnick , Eric Anderson , Xin Jiang , Christopher F. Bender , Gary Louis Bolton , Bradley William Caprathe , Chitase Lee , William Howard Roark
IPC分类号： C07D471/04 , C07D231/54 , C07D413/04 , C07D403/04 , C07D417/04 , C07D239/70 , C07D401/04
CPC分类号： C07D471/04 , C07D231/54 , C07D239/70 , C07D239/72 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要： The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein R1, R2, R3, R4, R5, R6, m, n, X and Y are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation.
摘要翻译： 本申请涉及：（a）式（I）化合物及其盐，其中R 1，R 2，R 3，R 4，R 5，R 6，m，n，X和Y如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别用于治疗和预防与氧化应激和炎症有关的疾病。
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8.发明授权Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17 有权抗氧化剂炎症调节剂：C-17具有氨基和其他修饰的齐墩果酸衍生物公开(公告)号：US09102681B2
公开(公告)日：2015-08-11
申请号：US13861208
申请日：2013-04-11
发明人： Eric Anderson , Xin Jiang , Melean Visnick
IPC分类号： C07D413/00 , C07C45/00 , C07C49/00 , C07D487/08 , C07J63/00 , C07C271/24 , C07C275/26 , C07C311/09 , C07D261/08 , C07D307/20
CPC分类号： C07C255/47 , C07C271/24 , C07C275/26 , C07C311/07 , C07C311/09 , C07C2603/52 , C07D209/56 , C07D211/44 , C07D231/12 , C07D261/08 , C07D295/195 , C07D307/20 , C07D487/08 , C07J63/008
摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
摘要翻译： 本发明提供但不限于具有下式的新型齐墩果酸衍生物：其中变量在本文中定义。 还提供了包含这种化合物的药物组合物，试剂盒和制品，用于制备化合物的方法和中间体，以及使用该化合物和组合物的方法。
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9.再颁专利Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring 有权抗氧化剂炎症调节剂：C环中饱和的齐墩果酸衍生物公开(公告)号：USRE45288E1
公开(公告)日：2014-12-09
申请号：US14080267
申请日：2013-11-14
发明人： Eric Anderson , Xin Jiang , Xiaofeng Liu , Melean Visnick
IPC分类号： C07D223/14 , C07D285/12 , C07D313/06 , C07D257/04 , C07C255/03
CPC分类号： C07D261/20 , C07C69/757 , C07D207/27 , C07D413/08 , C07J63/008
摘要： This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
摘要翻译： 本发明提供但不限于具有下式的新型齐墩果酸衍生物：其中变量在本文中定义。 还提供了包含这种化合物的药物组合物，试剂盒和制品，用于制备化合物的方法和中间体，以及使用该化合物和组合物的方法。
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10.发明授权公开(公告)号：US11078230B2
公开(公告)日：2021-08-03
申请号：US15622568
申请日：2017-06-14
发明人： Eric Anderson , Xiaofeng Liu , Andrea Decker
IPC分类号： C07J63/00 , C07C255/47 , A61K31/277
摘要： The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7, 8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.
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