- 专利标题： Anti-Abeta antibodies and uses thereof
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申请号： US16426585申请日： 2019-05-30
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公开(公告)号： US11084873B2公开(公告)日： 2021-08-10
- 发明人: Feng-Shiun Shie , Tsu-An Hsu , Chuan Shih , Santai Shen
- 申请人： National Health Research Institutes
- 申请人地址： TW Miaoli County
- 专利权人： National Health Research Institutes
- 当前专利权人： National Health Research Institutes
- 当前专利权人地址： TW Miaoli County
- 代理机构： Cesari & McKenna, LLP
- 主分类号： C07K16/18
- IPC分类号： C07K16/18 ; A61P25/28 ; G01N33/68 ; G01N33/60 ; A61K39/00
摘要：
An isolated antibody, comprising a light-chain CDR1 (L-CDR1) having the sequence of SEQ ID NO: 1, SEQ ID NO: 7, or SEQ ID NO: 14; a light-chain CDR2 (L-CDR2) having the sequence of SEQ ID NO: 2 or SEQ ID NO: 15; a light-chain CDR3 (L-CDR3) having the sequence of SEQ ID NO: 3, SEQ ID NO: 8, SEQ ID NO: 21, or SEQ ID NO: 24; a heavy-chain CDR1 (H-CDR1) having the sequence of SEQ ID NO: 4, SEQ ID NO: 9, SEQ ID NO: 11, SEQ ID NO: 16, or SEQ ID NO: 25; a heavy-chain CDR2 (H-CDR2) having the sequence of SEQ ID NO: 5, SEQ ID NO: 12, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 22, or SEQ ID NO: 26; and a heavy-chain CDR3 (H-CDR3) having the sequence of SEQ ID NO: 6, SEQ ID NO: 10, SEQ ID NO: 13, SEQ ID NO: 18, SEQ ID NO: 20, SEQ ID NO: 23, or SEQ ID NO: 27, wherein the antibody specifically binds to Aβ1-42 or an N-terminal modified form thereof.
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