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公开(公告)号：US20210163580A1
公开(公告)日：2021-06-03
申请号：US16770888
申请日：2018-12-06
发明人： Tsu-An Hsu , Hui-Chen Hung , Teng-Yuan Chang , Chuan Shih
IPC分类号： C07K16/18 , G01N33/574 , A61P35/00
摘要： An isolated antibody, comprising: heavy chain complementary determining regions CDR1, CDR2, and CDR3 of a heavy chain variable region sequence selected from SEQ ID NOs: 2, 6, 10, and 14; and light chain complementary determining regions CDR1, CDR2, and CDR3 of a light chain variable region sequence selected from SEQ ID NOs: 4, 8, 12, and 16; wherein the antibody binds specifically to a RSPO3 protein.
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公开(公告)号：US11623951B2
公开(公告)日：2023-04-11
申请号：US16770888
申请日：2018-12-06
发明人： Tsu-An Hsu , Hui-Chen Hung , Teng-Yuan Chang , Chuan Shih
IPC分类号： A61K39/395 , C07K16/18 , A61P35/00 , G01N33/574 , A61K39/00
摘要： Isolated antibodies that bind specifically to R-spondin 3 (RSPO3) are described. Also described herein are compositions containing the antibodies and methods of using the antibodies to treat cancer and detect RSPO3.
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公开(公告)号：US11084873B2
公开(公告)日：2021-08-10
申请号：US16426585
申请日：2019-05-30
发明人： Feng-Shiun Shie , Tsu-An Hsu , Chuan Shih , Santai Shen
摘要： An isolated antibody, comprising a light-chain CDR1 (L-CDR1) having the sequence of SEQ ID NO: 1, SEQ ID NO: 7, or SEQ ID NO: 14; a light-chain CDR2 (L-CDR2) having the sequence of SEQ ID NO: 2 or SEQ ID NO: 15; a light-chain CDR3 (L-CDR3) having the sequence of SEQ ID NO: 3, SEQ ID NO: 8, SEQ ID NO: 21, or SEQ ID NO: 24; a heavy-chain CDR1 (H-CDR1) having the sequence of SEQ ID NO: 4, SEQ ID NO: 9, SEQ ID NO: 11, SEQ ID NO: 16, or SEQ ID NO: 25; a heavy-chain CDR2 (H-CDR2) having the sequence of SEQ ID NO: 5, SEQ ID NO: 12, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 22, or SEQ ID NO: 26; and a heavy-chain CDR3 (H-CDR3) having the sequence of SEQ ID NO: 6, SEQ ID NO: 10, SEQ ID NO: 13, SEQ ID NO: 18, SEQ ID NO: 20, SEQ ID NO: 23, or SEQ ID NO: 27, wherein the antibody specifically binds to Aβ1-42 or an N-terminal modified form thereof.
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