Invention Grant
- Patent Title: Bacterial membrane nanoparticles as an immunotherapy system for cancer treatment
-
Application No.: US16562133Application Date: 2019-09-05
-
Publication No.: US11096899B2Publication Date: 2021-08-24
- Inventor: Shaoqin Gong , Zachary Scott Morris , Mingzhou Ye , Ravi Bhasker Patel , Paul M. Sondel
- Applicant: Wisconsin Alumni Research Foundation
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: Foley & Lardner LLP
- Main IPC: A61K39/39
- IPC: A61K39/39 ; A61K9/50 ; A61P35/00 ; A61K9/51 ; A61K39/00
Abstract:
Provided herein are nanoparticles comprising a polyplex core comprising one or more pH-responsive polymers and one or more anionic immune adjuvants, wherein each pH-responsive polymer comprises ionizable amine groups; and a shell of bacterial cell membrane components at least partially coating the polyplex core, wherein the bacterial cell membrane components comprise TLR 2 and/or TLR 4 agonists. Also provided are methods of stimulating an immune response in a mammal using the nanoparticle.
Public/Granted literature
- US20200078312A1 BACTERIAL MEMBRANE NANOPARTICLES AS AN IMMUNOTHERAPY SYSTEM FOR CANCER TREATMENT Public/Granted day:2020-03-12
Information query
