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公开(公告)号：US20200078312A1
公开(公告)日：2020-03-12
申请号：US16562133
申请日：2019-09-05
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Zachary Scott Morris , Mingzhou Ye , Ravi Bhasker Patel , Paul M. Sondel
Abstract: Provided herein are nanoparticles comprising a polyplex core comprising one or more pH-responsive polymers and one or more anionic immune adjuvants, wherein each pH-responsive polymer comprises ionizable amine groups; and a shell of bacterial cell membrane components at least partially coating the polyplex core, wherein the bacterial cell membrane components comprise TLR 2 and/or TLR 4 agonists. Also provided are methods of stimulating an immune response in a mammal using the nanoparticle.
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Patent Agency Ranking
公开(公告)号：US11911406B2
公开(公告)日：2024-02-27
申请号：US17171463
申请日：2021-02-09
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Mingzhou Ye
IPC: A61K31/7048 , A61K47/59 , A61P31/04 , A61K31/4409 , A61K31/7056 , A61K31/496 , A61K38/14 , A61K31/426 , A61K31/7036 , C08G69/10
CPC classification number: A61K31/7048 , A61K31/426 , A61K31/4409 , A61K31/496 , A61K31/7036 , A61K31/7056 , A61K38/14 , A61K47/595 , A61P31/04 , C08G69/10
Abstract: Provided herein are polymer-drug conjugates with enhanced antibacterial efficacy. These conjugates include a polymer comprising a plurality of masked cationic functional groups and an antibiotic drug linked to the cationic polymer by a pH-sensitive linker. The masked cationic functional groups may be converted in aqueous solution to free cationic functional groups faster at a pH below 7 than a pH above 7. The cationic functional groups may be masked as either an uncharged functional group or by an ion pair with a neighboring anionic functional group attached to the polymer. The pH-sensitive linker releases the drug faster in aqueous solution at or below a pre-determined pH value selected from a range of 4.5 to 7 than a pH value above 7.
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公开(公告)号：US11096899B2
公开(公告)日：2021-08-24
申请号：US16562133
申请日：2019-09-05
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Zachary Scott Morris , Mingzhou Ye , Ravi Bhasker Patel , Paul M. Sondel
Abstract: Provided herein are nanoparticles comprising a polyplex core comprising one or more pH-responsive polymers and one or more anionic immune adjuvants, wherein each pH-responsive polymer comprises ionizable amine groups; and a shell of bacterial cell membrane components at least partially coating the polyplex core, wherein the bacterial cell membrane components comprise TLR 2 and/or TLR 4 agonists. Also provided are methods of stimulating an immune response in a mammal using the nanoparticle.
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公开(公告)号：US20210244752A1
公开(公告)日：2021-08-12
申请号：US17171463
申请日：2021-02-09
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin GONG , Mingzhou Ye
IPC: A61K31/7048 , C08G69/10 , A61K47/59 , A61P31/04 , A61K31/7036 , A61K31/7056 , A61K31/496 , A61K38/14 , A61K31/426 , A61K31/4409
Abstract: Provided herein are polymer-drug conjugates with enhanced antibacterial efficacy. These conjugates include a polymer comprising a plurality of masked cationic functional groups and an antibiotic drug linked to the cationic polymer by a pH-sensitive linker. The masked cationic functional groups may be converted in aqueous solution to free cationic functional groups faster at a pH below 7 than a pH above 7. The cationic functional groups may be masked as either an uncharged functional group or by an ion pair with a neighboring anionic functional group attached to the polymer. The pH-sensitive linker releases the drug faster in aqueous solution at or below a pre-determined pH value selected from a range of 4.5 to 7 than a pH value above 7.
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公开(公告)号：US20230032473A1
公开(公告)日：2023-02-02
申请号：US17741298
申请日：2022-05-10
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Mingzhou Ye , Yi Zhao
IPC: A61K31/7084 , A61K9/127 , A61K47/02 , A61K47/22 , A61K31/496 , A61K31/192 , A61K31/65 , A61K31/7052 , A61K31/7036 , A61K31/513 , A61K31/522 , A61K31/4174 , A61K31/4196 , A61K31/506 , A61P31/04
Abstract: The present technology provides nanoparticles comprising an inorganic core and NAD+ or NADH, coated with a lipid bilayer, wherein the inorganic core is selected from calcium phosphate or a metal organic framework (MOF); the MOF comprises a transition metal ion coordinated to a coordinating ligand, wherein the transition metal ion is selected from the group consisting of zinc, iron, zirconium, copper, and cobalt ions, and the coordinating ligand is selected from an imidazolate ligand or a carboxylate ligand; and the nanoparticle has an average hydrodynamic diameter of from at least 50 nm to less than 1000 nm. Pharmaceutical compositions incorporating such nanoparticles and methods of treating sepsis and/or inflammation with such particles are also provided.
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公开(公告)号：US20220117904A1
公开(公告)日：2022-04-21
申请号：US17506614
申请日：2021-10-20
Applicant: Wisconsin Alumni Research Foundation
Inventor： Shaoqin Gong , Mingzhou Ye , David R. Andes
IPC: A61K9/51 , A61K9/50 , C08G63/688 , A61P31/04 , A61K31/496
Abstract: Provided herein are biodegradable polymers and nanoparticles comprising such polymers. The present nanoparticles deliver antibiotics to infected tissue with enhanced antibacterial efficacy. Thus, the present technology provides a nanoparticle comprising: a surface comprising one or more polysaccharides having specific binding affinity for bacteria; a core comprising a biodegradable polymer; and an antibacterial drug loaded within the core; wherein the biodegradable polymer comprises nitrogen-containing ionizable functional groups; the one or more polysaccharides having specific binding affinity for bacteria; and disulfide groups; the one or more polysaccharides are attached to the biodegradable polymer through phenyl boronic ester linkages; and the nanoparticle surface displays the polysaccharides such that the polysaccharide are available to bind to a bacterial cell surface.
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