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公开(公告)号：US20200078312A1
公开(公告)日：2020-03-12
申请号：US16562133
申请日：2019-09-05
摘要： Provided herein are nanoparticles comprising a polyplex core comprising one or more pH-responsive polymers and one or more anionic immune adjuvants, wherein each pH-responsive polymer comprises ionizable amine groups; and a shell of bacterial cell membrane components at least partially coating the polyplex core, wherein the bacterial cell membrane components comprise TLR 2 and/or TLR 4 agonists. Also provided are methods of stimulating an immune response in a mammal using the nanoparticle.
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公开(公告)号：US11096899B2
公开(公告)日：2021-08-24
申请号：US16562133
申请日：2019-09-05
摘要： Provided herein are nanoparticles comprising a polyplex core comprising one or more pH-responsive polymers and one or more anionic immune adjuvants, wherein each pH-responsive polymer comprises ionizable amine groups; and a shell of bacterial cell membrane components at least partially coating the polyplex core, wherein the bacterial cell membrane components comprise TLR 2 and/or TLR 4 agonists. Also provided are methods of stimulating an immune response in a mammal using the nanoparticle.
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公开(公告)号：US20200330567A1
公开(公告)日：2020-10-22
申请号：US16919191
申请日：2020-07-02
发明人： Jamey Weichert , Paul M. Sondel , Anatoly Pinchuk , Zachary Morris , Mario Otto , Bryan Bednarz
IPC分类号： A61K39/00 , A61K39/395 , A61K39/39 , A61K51/04
摘要： A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound that is differentially taken up by and retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by intratumorally injecting into (or treating via a separate method) at least one of the malignant solid tumors a composition that includes one or more agents capable of stimulating specific immune cells within the tumor microenvironment. In certain exemplary embodiments, the radiohalogenated compound has the formula: wherein R1 is a radioactive halogen isotope, n is 18 and R2 is —N+(CH3)3.
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公开(公告)号：US10736949B2
公开(公告)日：2020-08-11
申请号：US15652400
申请日：2017-07-18
发明人： Jamey Weichert , Paul M. Sondel , Anatoly Pinchuk , Zachary Morris , Mario Otto , Bryan Bednarz
IPC分类号： A61K39/00 , A61K39/395 , A61K39/39 , A61K51/04
摘要： A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound that is differentially taken up by and retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by intratumorally injecting into (or treating via a separate method) at least one of the malignant solid tumors a composition that includes one or more agents capable of stimulating specific immune cells within the tumor microenvironment. In certain exemplary embodiments, the radiohalogenated compound has the formula: wherein R1 is a radioactive halogen isotope, n is 18 and R2 is —N+(CH3)3.
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公开(公告)号：US20180015154A1
公开(公告)日：2018-01-18
申请号：US15652400
申请日：2017-07-18
发明人： Jamey Weichert , Paul M. Sondel , Anatoly Pinchuk , Zachary Morris , Mario Otto , Bryan Bednarz
摘要： A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound that is differentially taken up by and retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by intratumorally injecting into (or treating via a separate method) at least one of the malignant solid tumors a composition that includes one or more agents capable of stimulating specific immune cells within the tumor microenvironment. In certain exemplary embodiments, the radiohalogenated compound has the formula: wherein R1 is a radioactive halogen isotope, n is 18 and R2 is —N+(CH3)3.
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