Disclosed is to provide a composition which is derived from a natural product and exhibits an excellent effect of protecting cells from oxidative stress and a method for preparing the same. The extract and composition according to one aspect of the present disclosure are derived from a natural product, thus are safe. It can prevent, ameliorate and treat oxidative stress and neuron damage. Therefore, it allows to improve the quality of life of the elderly population without concerns about side effects and promote development of the related industry.