- 专利标题： Delivery of biomolecules to immune cells
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申请号： US15523142申请日： 2015-10-30
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公开(公告)号： US11111472B2公开(公告)日： 2021-09-07
- 发明人: Armon R. Sharei , Shirley Mao , George Hartoularos , Sophia Liu , Megan Heimann , Pamela Basto , Gregory Szeto , Siddharth Jhunjhunwala , Darrell Irvine , Robert S. Langer , Klavs F. Jensen , Ulrich H. Von Andrian
- 申请人： Massachusetts Institute of Technology , President and Fellows of Harvard College
- 申请人地址： US MA Cambridge; US MA Cambridge
- 专利权人： Massachusetts Institute of Technology,President and Fellows of Harvard College
- 当前专利权人： Massachusetts Institute of Technology,President and Fellows of Harvard College
- 当前专利权人地址： US MA Cambridge; US MA Cambridge
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 国际申请： PCT/US2015/058489 WO 20151030
- 国际公布： WO2016/070136 WO 20160506
- 主分类号： C12M1/42
- IPC分类号： C12M1/42 ; C12M3/06 ; A61K39/00 ; A61K45/06 ; A61K49/00 ; C12N15/87 ; G01N33/50 ; C12N5/0781 ; C12N5/0783 ; C12N5/0784
摘要：
A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.
公开/授权文献
- US20180142198A1 DELIVERY OF BIOMOLECULES TO IMMUNE CELLS 公开/授权日：2018-05-24
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