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公开(公告)号:US20220064584A1
公开(公告)日:2022-03-03
申请号:US17394125
申请日:2021-08-04
发明人: Armon R. Sharei , Shirley Mao , George Hartoularos , Sophia Liu , Megan Heimann , Pamela Basto , Gregory Szeto , Siddharth Jhunjhunwala , Darrell J. Irvine , Robert S. Langer , Klavs F. Jensen , Ulrich H. Von Andrian
IPC分类号: C12M1/42 , C12N15/87 , A61K39/00 , A61K45/06 , A61K49/00 , C12M3/06 , C12N5/0781 , C12N5/0783 , C12N5/0784 , G01N33/50
摘要: A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.
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公开(公告)号:US11111472B2
公开(公告)日:2021-09-07
申请号:US15523142
申请日:2015-10-30
发明人: Armon R. Sharei , Shirley Mao , George Hartoularos , Sophia Liu , Megan Heimann , Pamela Basto , Gregory Szeto , Siddharth Jhunjhunwala , Darrell Irvine , Robert S. Langer , Klavs F. Jensen , Ulrich H. Von Andrian
IPC分类号: C12M1/42 , C12M3/06 , A61K39/00 , A61K45/06 , A61K49/00 , C12N15/87 , G01N33/50 , C12N5/0781 , C12N5/0783 , C12N5/0784
摘要: A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.
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