There is provided a method of prestressing a beam-column joint with an appropriate ratio among the magnitudes of compression in the directions of X, Y, and Z axes. The method introduces prestress in a beam-column joint with a tensile introducing force generated by tensionally anchoring prestressing tendons that are arranged in PC beams extending along two horizontal directions (or X axis and Y axis) and PC columns extending along the vertical direction (or Z axis) and passed through the beam-column joint to bring the beam-column joint in triaxial compression, the prestress being introduced such that a diagonal tensile force T generated by an input shear force due to a seismic load of an extremely great earthquake that may occur very rarely will be cancelled completely or partially so as not to allow diagonal cracks to occur. The ratio of the prestresses introduced in the directions of the respective axes satisfies the following equation (1): σx:σy:σz=1:1:0.3−0.9   (1) where σx, σy, and σz are prestresses introduced in the directions of the X axis, the Y axis, and the Z axis respectively.