Methods and apparatus is provided for use in a medical procedure for image acquisition using a high-resolution imaging system, a three dimensional imaging system and a navigation system. A 3D imaging scan of an imaged portion of the surface of the patient is acquired using the three dimensional imaging system. Then, a first high-resolution imaging scan covering a first sub-portion of the imaged portion is acquired using the high-resolution imaging system, which is tracked by the navigation system. The 3D imaging scan and the first high-resolution imaging scan are combined to create an enhanced three dimensional image having contour lines to provide a visual representation of depth derived from depth information acquired from both the three dimensional imaging system and the high-resolution imaging system. Subsequent high resolution scans may then be stitched into the image and the updated image displayed in real-time.