- 专利标题： Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases
-
申请号： US16495455申请日： 2018-03-23
-
公开(公告)号： US11117892B2公开(公告)日： 2021-09-14
- 发明人: Hwan Geun Choi , Eunhwa Ko , Joong-heui Cho , Jung Beom Son , Yi Kyung Ko , Jin-Hee Park , So Young Kim , Seock Yong Kang , Seungyeon Lee , Hee Yoon Ryu , Nam Doo Kim , Sang Bum Kim , Sun-Hwa Lee , Dayea Kim , Sun Joo Lee , Sungchan Cho , Kyu-Sun Lee , Kweon Yu , Miri Choi , Ja Wook Koo , Hyang-Sook Hoe
- 申请人： DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION , KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY
- 申请人地址： KR Daegu; KR Daejeon; KR Daegu
- 专利权人： DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION,KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY,DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY
- 当前专利权人： DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION,KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY,DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY
- 当前专利权人地址： KR Daegu; KR Daejeon; KR Daegu
- 代理机构： Caesar Rivise, PC
- 优先权： KR10-2017-0036845 20170323
- 国际申请： PCT/KR2018/003459 WO 20180323
- 国际公布： WO2018/174650 WO 20180927
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61P25/28
摘要：
The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.