公开(公告)号：US11117892B2

公开(公告)日：2021-09-14

申请号：US16495455

申请日：2018-03-23

申请人： DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Hwan Geun Choi ,  Eunhwa Ko ,  Joong-heui Cho ,  Jung Beom Son ,  Yi Kyung Ko ,  Jin-Hee Park ,  So Young Kim ,  Seock Yong Kang ,  Seungyeon Lee ,  Hee Yoon Ryu ,  Nam Doo Kim ,  Sang Bum Kim ,  Sun-Hwa Lee ,  Dayea Kim ,  Sun Joo Lee ,  Sungchan Cho ,  Kyu-Sun Lee ,  Kweon Yu ,  Miri Choi ,  Ja Wook Koo ,  Hyang-Sook Hoe

IPC分类号： C07D471/04 ,  A61P25/28

摘要： The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.