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公开(公告)号：US20240018119A1
公开(公告)日：2024-01-18
申请号：US17928044
申请日：2021-04-05
发明人： Minsoo Song , Chun Young Im , Ga Young Park , Eun Bi Ko , Jihee Kang , Seri Bae , Soong-Hyun Kim , Yoojin Park , Eunhye Lee , Yujeong Choi , Eunju Cha , Chang Hoon Seo , Chan Young Shin , Kyoung Ja Kwon , Darine Froy Mabunga , Donghyun Park , Hee Jong Hwang , Ryeong Eun Kim , Suresh Paudel , Se Jin Jeon , Kyu Suk Cho
IPC分类号： C07D401/12 , C07D209/14 , C07D417/12 , C07D471/04 , C07C233/11 , C07D211/22 , C07D401/14
CPC分类号： C07D401/12 , C07D209/14 , C07D417/12 , C07D401/14 , C07C233/11 , C07D211/22 , C07D471/04
摘要： Disclosed are a carboxamide derivative and a pharmaceutical composition comprising same as an active ingredient for use in preventing or treating mental illness. The derivative is superbly effective in a triple reuptake inhibitor of serotonin, norepinephrine, and dopamine, and thus can be effectively used in treating mental illness.
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公开(公告)号：US20230248740A1
公开(公告)日：2023-08-10
申请号：US17953867
申请日：2022-09-27
申请人： DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION , NATIONAL CANCER CENTER , SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
发明人： Hwan Geun Choi , Jong Bae Park , Eunhwa Ko , Jung Beom Son , Nam Doo Kim , Seung Hoon Lee , Do-Hyun Nam
IPC分类号： A61K31/5513 , A61P35/04 , A61K31/415 , A61K31/4365 , A61K31/437 , A61K31/506 , A61K31/5377 , C07K16/22
CPC分类号： A61K31/5513 , A61K31/415 , A61K31/437 , A61K31/506 , A61K31/4365 , A61K31/5377 , A61P35/04 , C07K16/22
摘要： Disclosed is a pharmaceutical composition for the prevention or treatment of brain cancer, containing a compound capable of penetrating the blood-brain barrier as an active ingredient, the pharmaceutical composition for the prevention or treatment of brain cancer is capable of efficiently penetrating the blood-brain barrier of the brain to thereby effectively inhibit LRRK2 protein expression, and is thus useful in the prevention or treatment of brain cancer.
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公开(公告)号：US20220106307A1
公开(公告)日：2022-04-07
申请号：US17398478
申请日：2021-08-10
申请人： DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION , KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人： Hwan Geun CHOI , Eunhwa KO , Joong-heui CHO , Jung Beom SON , Yi Kyung KO , Jin-Hee PARK , So Young KIM , Seock Yong KANG , Seungyeon LEE , Hee Yoon RYU , Nam Doo KIM , Sang Bum KIM , Sun-Hwa LEE , Dayea KIM , Sun Joo LEE , Sungchan CHO , Kyu-Sun LEE , Kweon YU , Miri CHOI , Ja Wook KOO , Hyang-Sook HOE
IPC分类号： C07D471/04 , A61P25/28
摘要： The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.
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公开(公告)号：US10442796B2
公开(公告)日：2019-10-15
申请号：US15998791
申请日：2018-08-16
发明人： Tae Bo Sim , Woo Young Hur , Chi Man Song , Ho Jong Yoon , Seung Hye Choi , Han Na Cho , Hwan Geun Choi , Nam Doo Kim , Jung Beom Son , Eun Hwa Ko , Hyun Kyoung Kim , Joong Heui Cho , Seock Yong Kang , So Young Kim , Yi Kyung Ko , Seung Yeon Lee , Suk Kyoon Yoon , Jae Hyun Bae
IPC分类号： C07D409/12 , A61P35/02 , A61K31/381 , A61K31/4436 , C07D333/10 , C07D409/14
摘要： The present invention relates to a novel 2,3,5-substituted thiophene compound having inhibitory activity against kinases, an anticancer agent including the compound as an active ingredient, and a method for preparing the compound.
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公开(公告)号：US20190016703A1
公开(公告)日：2019-01-17
申请号：US16066150
申请日：2016-12-29
发明人： Nathanael S. GRAY , James BRADNER , Pasi JANNE , Jaebong JANG , Hwan Geun CHOI , Eunhwa KO , Joong-Heui CHO
IPC分类号： C07D401/14 , A61P35/00 , A61K47/54 , A61K47/18 , A61K47/08
摘要： The present invention provides bifunctional compounds which act as protein degradation inducing moieties for a HER family protein, such as Her3. The present invention also provides methods for the targeted degradation of a HER family protein through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to the HER family protein which can be utilized in the treatment of disorders modulated by a HER family protein.
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公开(公告)号：US20230374060A1
公开(公告)日：2023-11-23
申请号：US17914283
申请日：2021-03-24
发明人： Soong-Hyun Kim , Eun Bi Ko , Minsoo Song , Ga Young Park , Eunhye Lee , Seri Bae , Jihee Kang , Yoojin Park , Youjeong Choi
IPC分类号： C07J9/00
CPC分类号： C07J9/00
摘要： The present invention relates to a novel method for preparing inotodiol, which is different from the existing method for preparing inotodiol and has a high yield of inotodiol, so it can be effectively used for preparing and mass-producing inotodiol.
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公开(公告)号：US20230212144A1
公开(公告)日：2023-07-06
申请号：US17927973
申请日：2021-05-25
发明人： Minsoo Song , Ga Young Park , Eun Bi Ko , Jihee Kang , Chun Young Im , Seri Bae , Soong-Hyun Kim , Yoojin Park , Eunhye Lee , Yujeong Choi , Sang Bum Kim , Oh-Bin Kwon , Chan Young Shin , Kyoung Ja Kwon , Suresh Paudel , Se Jin Jeon , Kyu Suk Cho
IPC分类号： C07D401/14 , C07D403/04 , C07D401/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D403/14 , C07D491/056
CPC分类号： C07D401/14 , C07D403/04 , C07D401/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D403/14 , C07D491/056
摘要： The present invention relates to a 5-membered heteroaryl derivative containing an N, and a pharmaceutical composition for use in preventing or treating mental disorders, containing same as an active ingredient, wherein the derivative is excellent in the triple reuptake inhibitory effect of serotonin, norepinephrine, and dopamine, and thus can be useful in the treatment of mental disorders.
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公开(公告)号：US20230212121A1
公开(公告)日：2023-07-06
申请号：US17928032
申请日：2021-04-05
发明人： Minsoo Song , Chun Young Im , Ga Young Park , Eun Bi Ko , Jihee Kang , Seri Bae , Soong-Hyun Kim , Yoojin Park , Eunhye Lee , Yujeong Choi , Jeongmin Joo , Sion Lee , Chan Young Shin , Kyoung Ja Kwon , Hee Jong Hwang , Suresh Paudel , Se Jin Jeon , Kyu Suk Cho
IPC分类号： C07D211/14 , C07D401/12 , C07D215/36 , C07C307/02 , C07D401/04
CPC分类号： C07D211/14 , C07D401/12 , C07D215/36 , C07C307/02 , C07D401/04
摘要： Disclosed are a sulfonamide derivative and a pharmaceutical composition comprising same as an active ingredient for use in preventing or treating mental illness. The derivative is superbly effective in a triple reuptake inhibitor of serotonin, norepinephrine, and dopamine, and thus can be effectively used in treating mental illness.
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9.发明授权公开(公告)号：US11285226B2
公开(公告)日：2022-03-29
申请号：US16677596
申请日：2019-11-07
申请人： Daegu-Gyeongbuk Medical Innovation Foundation , KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL , Kyungpook National University Industry-Academic Cooperation Foundation
发明人： Sung Yeoun Hwang , Sung Jin Cho , Jina Kim , Jungwook Chin , Hayoung Hwang , In-Kyu Lee , Yong-Hyun Jeon , Jaetae Lee , Jae-Han Jeon , Sang Wook Kim
IPC分类号： A61K51/02 , A61K31/396 , A61K31/397 , A61K31/496 , C07D265/28 , C07D241/04 , C07D203/08 , A61K31/535 , A61P35/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/407 , A61K31/4192 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/5375 , A61K31/695
摘要： The present invention relates to an aryl ethene derivative, for inhibiting an estrogen-related receptor gamma (ERRγ) activity, a prodrug of same, a solvate of same, a stereoisomer of same or pharmaceutically acceptable salts of same, and a pharmaceutical composition containing same as an active ingredient.
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公开(公告)号：US11208412B2
公开(公告)日：2021-12-28
申请号：US16488194
申请日：2018-02-22
申请人： DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION , NATIONAL CANCER CENTER , SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
发明人： Hwan Geun Choi , Jong Bae Park , Eunhwa Ko , Jung Beom Son , Joong-heui Cho , Yi Kyung Ko , Jin-Hee Park , So Young Kim , Seock Yong Kang , Seungyeon Lee , Nam Doo Kim , Yunho Lee , Sun-Hwa Lee , Dayea Kim , Sun Joo Lee , Jae Hyun Bae , Eunmi Hong , Tae-ho Jang , Sang Bum Kim , Seung Hoon Lee , Do-Hyun Nam
IPC分类号： C07D487/04 , A61P35/00 , A61P29/00 , A61P25/28 , A61K31/519
摘要： The present invention relates to a novel pyrrolo-pyrimidine derivative compound, a preparation method therefor, and a pharmaceutical composition comprising the same compound as an effective ingredient for preventing or treating a protein kinase-related disease. The compound represented by Chemical Formula 1 according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an effective ingredient has outstanding inhibitory activity against LRRK2 kinase and against phosphorylation in the NIH-3T3 cell line, which is an LRRK2-expressing cell line, and NCC01 and 448T cell lines, which are both derived from patients with brain tumors. Verified to have inhibitory activity against various protein kinases in addition to LRRK2, the compound can find effective applications in the treatment or prevention of protein kinase-related diseases.
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