- Patent Title: Genetically engineered gas vesicle gene clusters, genetic circuits, vectors, prokaryotic cells, compositions, methods and systems for contrast-enhanced imaging
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Application No.: US15663635Application Date: 2017-07-28
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Publication No.: US11118210B2Publication Date: 2021-09-14
- Inventor: Raymond W. Bourdeau , Anupama Lakshmanan , Arash Farhadi , Mikhail G. Shapiro , Audrey Lee-Gosselin
- Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Applicant Address: US CA Pasadena
- Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Current Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Current Assignee Address: US CA Pasadena
- Agency: Steinfl + Bruno LLP
- Main IPC: C12Q1/10
- IPC: C12Q1/10 ; A61K49/22 ; A61K49/18 ; C12N15/74 ; C07K14/32 ; C12N15/70 ; C07K14/195
Abstract:
Hybrid gas vesicle gene cluster (GVGC) configured for expression in a prokaryotic host are described comprising gas vesicle assembly (GVA) genes native to a GVA prokaryotic species and capable of being expressed in a functional form in the prokaryotic host, and one or more gas vesicle structural (GVS) genes native to one or more GVS prokaryotic species, at least one of the one or more GVS prokaryotic species different from the GVA prokaryotic species, and related gas vesicle reporting (GVR) genetic circuits, genetic, vectors, engineered cells, and related compositions methods and systems to produce GVs, hybrid GVGC and/or image a target site.
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