A read command to read a target memory die of a memory sub-system is received from a host system via a host-side interface of an active input/output (I/O) expander. The active I/O expander identifies a page address corresponding to the target memory die and decodes the read command to send to a memory stack associated with the page address corresponding to the target memory die. Read data is received via a memory-side interface of the active I/O expander from the memory stack including the target memory die. A signal conditioning operation is performed on the read data to generate conditioned read data. The active I/O expander sends, via the host-side interface, the conditioned read data to the host system.