A wireless communication device can include an antenna configured to sense a radio frequency (RF) signal. The wireless communication device can include signal estimation circuitry configured to generate estimates of amplitude and frequency for unmodulated spurs within the RF signal. The wireless communication device can further include multi-tone generator circuitry coupled to the signal estimation circuitry and configured to generate a composite spur cancellation signal based on the estimates of amplitude and frequency for unmodulated spurs within the RF signal. The wireless communication device can further include adder circuitry configured to subtract the spur cancellation signal from the RF signal to generate a spur cancelled signal.