Invention Grant
- Patent Title: Methods for treating melanoma using small molecules
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Application No.: US16469865Application Date: 2017-12-15
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Publication No.: US11149028B2Publication Date: 2021-10-19
- Inventor: Dmitriy Minond , Gregg B. Fields , Marcello Giulianotti
- Applicant: NOVA SOUTHEASTERN UNIVERSITY , AUBURN UNIVERSITY , FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES , TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
- Applicant Address: US FL Fort Lauderdale; US AL Auburn; US FL Boca Raton; US FL Port St. Lucie
- Assignee: NOVA SOUTHEASTERN UNIVERSITY,AUBURN UNIVERSITY,FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES,TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
- Current Assignee: NOVA SOUTHEASTERN UNIVERSITY,AUBURN UNIVERSITY,FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES,TORREY PINES INSTITUTE FOR MOLECULAR STUDIES
- Current Assignee Address: US FL Fort Lauderdale; US AL Auburn; US FL Boca Raton; US FL Port St. Lucie
- Agency: Fleit Intellectual Property Law
- Agent Paul D. Bianco; Katharine Davis
- International Application: PCT/US2017/066876 WO 20171215
- International Announcement: WO2018/112443 WO 20180621
- Main IPC: A61K31/495
- IPC: A61K31/495 ; C07D403/14 ; A61P35/02 ; G01N33/50 ; G01N33/564 ; G01N33/566
Abstract:
The invention provides methods for treating cancers, such as melanoma and/or metastatic melanoma, using compounds that interact with and/or inhibit cellular proteins lamin A/C, ATP-dependent RNA helicase DDX1 (DDX1), heterogeneous nuclear ribonuclear protein H1/H2 (hnRNP H2), and/or heterogeneous nuclear ribonuclear protein A2/B1 (hnRNP A2/B1). The invention additionally provides a method for identifying compounds active against melanoma cells.
Public/Granted literature
- US20200062736A1 METHODS FOR TREATING MELANOMA USING SMALL MOLECULES AND SMALL INTERFERING RNA (siRNA) Public/Granted day:2020-02-27
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