公开(公告)号：US12027630B2

公开(公告)日：2024-07-02

申请号：US18195982

申请日：2023-05-11

申请人： Auburn University

发明人： Minseo Park ,  Michael C. Hamilton ,  Shiqiang Wang ,  Kosala Yapa Bandara

IPC分类号： H01L29/786 ,  H01L21/42 ,  H01L21/477 ,  H01L21/768

CPC分类号： H01L29/7869 ,  H01L21/42 ,  H01L21/477 ,  H01L21/76868

摘要： A thin-film transistor comprises an annealed layer comprising crystalline zinc oxide. A passivation layer is adjacent to the thin-film transistor. The passivation layer has a thickness and material composition such that when a dose of radiation from a radiation source irradiates the thin-film transistor, a portion of the dose that includes an approximate maximum concentration of the dose is located within the annealed layer. The annealed layer has a thickness and threshold displacement energies after it has been annealed such that: a) a difference between a transfer characteristic value of the thin-film transistor before and after the dose is less than a first threshold; and b) a difference between a transistor output characteristic value of the thin-film before and after the dose is less than a second threshold. The thresholds are based on a desired performance of the thin-film transistor.

公开(公告)号：US12022802B2

公开(公告)日：2024-07-02

申请号：US18325290

申请日：2023-05-30

申请人： THE UNITED STATES OF AMERICA AS REPRESENTED BY THE FEDERAL BUREAU OF INVESTIGATION, DEPARTMENT OF JUSTICE ,  AUBURN UNIVERSITY

发明人： Kathleen Giles ,  Thomas Craig Angle ,  Lowell Paul Waggoner ,  Thomas Passler ,  Terrence Fischer

IPC分类号： A01K15/02

CPC分类号： A01K15/02

摘要： Provided herein are methods of making a training aid for detecting a biohazard, and related devices and methods of using the device, including a canine training aid. The devices are made by positioning a polymer layer in proximity and physically separated from a biological material, so that volatile organic compounds contact and bind or infuse the polymer layer. The device is made render-safe by inactivating the infused polymer layer, such as by heating to a temperature sufficient to inactivate biological agents on or in the analyte-infused polymer layer. The device can be stored in a substantially air-tight configuration for subsequent use in training, such as canine and/or or artificial detectors.

公开(公告)号：US20240158584A1

公开(公告)日：2024-05-16

申请号：US18508979

申请日：2023-11-14

申请人： AUBURN UNIVERSITY

发明人： Burak Aksoy ,  Zhihua Jiang ,  Navid E. Alamdari

IPC分类号： C08J3/075

CPC分类号： C08J3/075 ,  C08J2305/06 ,  C08J2389/00

摘要： A method of making a hydrogel by treating a cellulosic biomass containing pectin and protein with an aqueous acidic solution at a pH, at a temperature, and for a time sufficient to cause formation of at least a gel fraction containing the hydrogel.

公开(公告)号：US20240075027A1

公开(公告)日：2024-03-07

申请号：US18320470

申请日：2023-05-19

申请人： Auburn University

发明人： Amit Kumar Mitra ,  Harish Kumar

IPC分类号： A61K31/498 ,  A61K31/454 ,  A61K31/69 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61P35/00

CPC分类号： A61K31/498 ,  A61K31/454 ,  A61K31/69 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61P35/00

摘要： The present invention relates to compositions comprising clofazimine and methods for treating cancer. In various embodiments, the compositions and methods further comprise a proteasome inhibitor and/or immunomodulatory drug. The compositions and methods of the present invention may be used for naïve cancers as well as those that have developed resistance to proteasome inhibitors and/or immunomodulatory drugs.

公开(公告)号：US11826632B2

公开(公告)日：2023-11-28

申请号：US17179698

申请日：2021-02-19

申请人： AUBURN UNIVERSITY

发明人： Michael Edgar Zabala ,  Vitale Kyle Castellano ,  Jacob Stuart Larson ,  Austin J. Harris

IPC分类号： A63B71/12 ,  A41D13/015 ,  B29C65/48 ,  B33Y50/02 ,  B33Y80/00

CPC分类号： A63B71/1225 ,  A41D13/0156 ,  B29C65/48 ,  A63B2071/1258 ,  B33Y50/02 ,  B33Y80/00

摘要： A method for manufacturing individualized protective gear such as pads based on a body scan, and the resulting pads, are disclosed herein. A body scan is taken of a wearer-defined area for a desired set of pads. The scan is converted to a mesh model. The mesh model is used to define a first surface of the pad shell and then translationally or orthogonally offset to provide a second surface of the pad shell. The mesh is also flattened to provide a liner for the pad. The shell may be manufactured using additive printing technology. The shell and the liner are then attached, such as by adhesive.

公开(公告)号：US20230340400A1

公开(公告)日：2023-10-26

申请号：US17787330

申请日：2021-01-21

申请人： AUBURN UNIVERSITY

发明人： Yi WANG ,  Jun FENG ,  Yuechao MA

IPC分类号： C12N9/10 ,  C12N1/20 ,  C12N15/52 ,  C12P7/62 ,  C12N15/74

CPC分类号： C12N1/20 ,  C12N9/1029 ,  C12N15/52 ,  C12N15/74 ,  C12P7/62 ,  C12Y203/01084 ,  C12R2001/145

摘要： Microorganisms and microbial production methods for the biosynthesis of ester compounds are provided. Useful examples employ microorganisms that have been genetically modified to express alcohol acyltransferases, either from other species or that have been modified to increase their activity in catalyzing the esterification of alcohols. Additional useful examples employ microorganisms that have been genetically modified to express lipases, either from other species or that have been modified to increase their activity in catalyzing the esterification of organic acids. Additional modifications are presented that significantly increase ester production.

公开(公告)号：US20230338462A1

公开(公告)日：2023-10-26

申请号：US18311169

申请日：2023-05-02

申请人： Auburn University ,  Edward Via College of Osteopathic Medicine - Auburn

发明人： Tatiana I. SAMOYLOVA ,  Alexandre M. SAMOYLOV ,  Kenny V. BROCK ,  Anna M. COCHRAN ,  James W. GILLESPIE

IPC分类号： A61K38/10 ,  C07K7/06 ,  A61P35/00 ,  A61K38/08 ,  A61K47/69 ,  C07K7/08

CPC分类号： A61K38/10 ,  C07K7/06 ,  A61P35/00 ,  A61K38/08 ,  A61K47/6901 ,  C07K7/08

摘要： Disclosed are recombinant bacteriophage constructs and related exogenous peptide sequences for generating immune responses against CD47. The disclosed recombinant phage constructs bind to antibodies against CD47 and can be administered to an animal to generate an immune response against CD47, including generating anti-CD47 antibodies. The disclosed recombinant phage may comprise an amino acid sequence of CD47, epitopic fragments, variants, or functional mimics thereof. Also disclosed are methods for making and selecting such recombinant phage constructs and compositions that comprise such constructs (e.g., compositions for inducing an immune response against CD47 including pharmaceutical or veterinary compositions used as vaccines). Also disclosed are recombinant polynucleotides comprising genomic nucleic acid of the recombinant phage constructs disclosed herein.

公开(公告)号：US20230333128A1

公开(公告)日：2023-10-19

申请号：US17616338

申请日：2020-06-26

申请人： INNAMED, INC. ,  AUBURN UNIVERSITY

发明人： Subramaniam SOMASUNDARAM ,  Anup SINGH ,  Eshwar INAPURI ,  Christopher J. EASLEY ,  Hunho JO

IPC分类号： G01N33/94 ,  C12Q1/6804 ,  G01N33/543

CPC分类号： G01N33/9493 ,  C12Q1/6804 ,  G01N33/5438

摘要： Methods and apparatuses, including assays, for detection and/or quantification of tacrolimus that utilize nucleic acid-based nanostructures linked to tacrolimus. In particular, described herein are biosensors having a sensing mechanism configured to react to a tacrolimus-specific binding agent, such as an aptamer or antibody that binds tacrolimus. In some variations, these methods and apparatuses may be configured to provide an electrochemical read-out in which the nucleic acid-based nanostructure is operated in conjunction with a tacrolimus-specific binding agent for sample quantification. A biosensor or a set of biosensors as described herein can be used as a standalone measurement system for tacrolimus and/or as part of a multiplexed cartridge for multiple analytes.

公开(公告)号：US20230321314A1

公开(公告)日：2023-10-12

申请号：US18201463

申请日：2023-05-24

申请人： AUBURN UNIVERSITY

发明人： Shelby D. WORLEY ,  Royall M. BROUGHTON ,  Idris CERKEZ ,  Buket DEMIR

IPC分类号： A61L15/44 ,  A61L26/00 ,  A61L31/16 ,  A01N43/50 ,  A01N25/34 ,  A61L15/60 ,  A61L31/10 ,  A61L31/14 ,  A61L31/04 ,  A61L15/24 ,  A61L15/46 ,  A61L31/08

CPC分类号： A61L15/44 ,  A01N25/34 ,  A01N43/50 ,  A61L15/24 ,  A61L15/46 ,  A61L15/60 ,  A61L26/0066 ,  A61L31/048 ,  A61L31/08 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/204 ,  A61L2300/404 ,  A61L2420/02

摘要： The present disclosure provides fibrous composition comprising a soluble or a dispersible N-halamine, for example 1-chloro-2,2,5,5-tetramethyl-4-imidazolidinone (i.e., compound I). Additionally, the disclosure provides methods for producing the fibrous compositions comprising a soluble or a dispersible N-halamine as well as methods for protecting a person from an infection using the fibrous compositions comprising a soluble or a dispersible N-halamine. The compositions and methods according to the present disclosure provide several advantages, such as stability, less time to provide sufficient antimicrobial inactivation, and are inexpensive and require lower amount of active concentrations to be effective.

公开(公告)号：US20230265380A1

公开(公告)日：2023-08-24

申请号：US18041033

申请日：2021-08-10

申请人： ABNATURA INC. ,  AUBURN UNIVERSITY

发明人： Jean-Marc JUTEAU ,  Marc SIROIS ,  Joe KLOEPPER ,  John MCINROY

IPC分类号： C12N1/20 ,  A01N63/22

CPC分类号： C12N1/205 ,  A01N63/22 ,  C12R2001/07

摘要： A novel bacteria strain Bacillus velezensis ABN1001 was deposited at the International Depositary Authority of Canada. The bacteria, or mutants thereof, or metabolites produced by the bacteria, can be used in compositions for controlling plant disease, treating plant disease, and/or promoting plant growth.