- 专利标题： 4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-7-carboxamides
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申请号： US16638683申请日： 2018-08-09
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公开(公告)号： US11161825B2公开(公告)日： 2021-11-02
- 发明人: Jörg Weiske , Carlo Stresemann , Stefan Nikolaus Gradl , Ulrike Röhn , Clara Christ , Holger Steuber , Manfred Husemann , Norbert Schmees , Kai Thede , Stephan Siegel , Antonius Ter Laak
- 申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft
- 申请人地址： DE Leverkusen; DE Berlin
- 专利权人： Bayer Aktiengesellschaft,Bayer Pharma Aktiengesellschaft
- 当前专利权人： Bayer Aktiengesellschaft,Bayer Pharma Aktiengesellschaft
- 当前专利权人地址： DE Leverkusen; DE Berlin
- 代理机构： Morrison & Foerster LLP
- 优先权： EP17186334 20170815,EP18154895 20180202,EP18175162 20180530
- 国际申请： PCT/EP2018/071649 WO 20180809
- 国际公布： WO2019/034532 WO 20190221
- 主分类号： C07D243/12
- IPC分类号： C07D243/12 ; C07D401/06 ; C07D403/06 ; C07D409/06 ; C07D413/06
摘要：
The present invention covers 4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-7-carboxamide compounds of general formula (I): in which R1, R2a, R2b, R2c, R3a, R3b, R4a, R4b, R5 and X are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer, as a sole agent or in combination with other active ingredients.
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