-
公开(公告)号：US20210032212A1
公开(公告)日：2021-02-04
申请号：US17046143
申请日：2019-04-03
发明人： Jorma Hassfeld , Stefan Nikolaus Gradl , Philipp Rubenbauer , Henricus Nicolaas Sebastiaan VAN DER HAAS , Reinerus Gerardus GIELING
IPC分类号： C07D249/12 , C07D405/12
摘要： The present invention provides methods for the preparation of Compound (I): Compound (I), the use of intermediates for the preparation of said compound and its crystalline form A.
-
公开(公告)号：US20200369633A1
公开(公告)日：2020-11-26
申请号：US16635504
申请日：2018-08-02
申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.
发明人： Manuel Ellermann , Stefan Nikolaus Gradl , Charlotte Christine Kopitz , Martin Lange , Adrian Tersteegen , Philip Lienau , Christa Hegele-Hartung , Detlev Sülzle , Timothy A. Lewis , Heidi Greulich , Xiaoyun Wu , Matthew Meyerson , Alex Burgin
IPC分类号： C07D273/04 , C07D413/10 , C07D413/12 , C07D417/10 , C07D491/107 , C07D495/10 , C07D471/04
摘要： The present invention provides dihydrooxydiazinone compounds of general formula (I): in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
-
公开(公告)号：US11787797B2
公开(公告)日：2023-10-17
申请号：US17161615
申请日：2021-01-28
申请人： BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGESELLSCHAFT , THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE GENERAL HOSPITAL CORPORATION
发明人： Stefan Nikolaus Gradl , Duy Nguyen , Knut Eis , Judith Günther , Timo Stellfeld , Andreas Janzer , Sven Christian , Thomas Mueller , Sherif El Sheikh , Han Jie Zhou , Changjia Zhao , David B. Sykes , Steven James Ferrara , Kery Liu , Simon Anthony Herbert , Claudia Merz , Michael Niehues , Carl Friedrich Nising , Martina Schäfer , Katja Zimmermann , Jörg Knäblein , Kai Thede , Thomas Faupel
IPC分类号： C07D471/04 , A61P35/00 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C12N1/20 , C12P17/18
CPC分类号： C07D471/04 , A61P35/00 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C12N1/20 , C12P17/18 , C12P17/182 , C12P17/188
摘要： The present invention provides triazolone compounds of general formula (I):
in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.-
公开(公告)号：US11427553B2
公开(公告)日：2022-08-30
申请号：US16635504
申请日：2018-08-02
申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.
发明人： Manuel Ellermann , Stefan Nikolaus Gradl , Charlotte Christine Kopitz , Martin Lange , Adrian Tersteegen , Philip Lienau , Christa Hegele-Hartung , Detlev Sülzle , Timothy A. Lewis , Heidi Greulich , Xiaoyun Wu , Matthew Meyerson , Alex Burgin
IPC分类号： C07D273/04 , C07D413/10 , C07D413/12 , C07D417/10 , C07D471/04 , C07D491/107 , C07D495/10
摘要： The present invention provides dihydrooxydiazinone compounds of general formula (I): in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
-
公开(公告)号：US11713304B2
公开(公告)日：2023-08-01
申请号：US17407951
申请日：2021-08-20
申请人： BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGESELLSCHAFT , THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE GENERAL HOSPITAL CORPORATION
发明人： Stefan Nikolaus Gradl , Duy Nguyen , Knut Eis , Judith Günther , Timo Stellfeld , Andreas Janzer , Sven Christian , Thomas Müller , Sherif El Sheikh , David B. Sykes , Steven James Ferrara , Michael Kröber , Claudia Merz , Michael Niehues , Martina Schäfer , Katja Zimmermann , Carl Friedrich Nising
IPC分类号： A61P35/00 , C07D401/12 , C07D249/12 , C07D403/12 , C07D405/12 , C07D413/12 , A61K45/06
CPC分类号： C07D401/12 , A61P35/00 , C07D249/12 , C07D403/12 , C07D405/12 , C07D413/12 , A61K45/06
摘要： The present invention provides triazolone compounds of general formula (I):
in which R1, R2, R3, R4, and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and prophylaxis of diseases, in particular hyperproliferative disorders, as a sole agent or in combination with other active ingredients.-
公开(公告)号：US10968216B2
公开(公告)日：2021-04-06
申请号：US16345178
申请日：2017-10-25
申请人： BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGESELLSCHAFT , THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE GENERAL HOSPITAL CORPORATION
发明人： Stefan Nikolaus Gradl , Duy Nguyen , Knut Eis , Judith Günther , Timo Stellfeld , Andreas Janzer , Sven Christian , Thomas Mueller , Sherif El Sheikh , Han Jie Zhou , Changjia Zhao , David B. Sykes , Steven James Ferrara , Kery Liu , Simon Anthony Herbert , Claudia Merz , Michael Niehues , Carl Friedrich Nising , Martina Schäfer , Katja Zimmermann , Jörg Knäblein , Kai Thede , Thomas Faupel
IPC分类号： C07D471/04 , A61P35/00 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C12N1/20 , C12P17/18
摘要： The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
-
公开(公告)号：US11365179B2
公开(公告)日：2022-06-21
申请号：US17046143
申请日：2019-04-03
发明人： Jorma Hassfeld , Stefan Nikolaus Gradl , Philipp Rubenbauer , Henricus Nicolaas Sebastiaan Van Der Haas , Reinerus Gerardus Gieling
IPC分类号： C07D249/12 , C07D405/12 , A61P35/00 , A61K31/4196
摘要： The present invention provides methods for the preparation of Compound (I): Compound (I), the use of intermediates for the preparation of said compound and its crystalline form A.
-
公开(公告)号：US11161825B2
公开(公告)日：2021-11-02
申请号：US16638683
申请日：2018-08-09
发明人： Jörg Weiske , Carlo Stresemann , Stefan Nikolaus Gradl , Ulrike Röhn , Clara Christ , Holger Steuber , Manfred Husemann , Norbert Schmees , Kai Thede , Stephan Siegel , Antonius Ter Laak
IPC分类号： C07D243/12 , C07D401/06 , C07D403/06 , C07D409/06 , C07D413/06
摘要： The present invention covers 4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-7-carboxamide compounds of general formula (I): in which R1, R2a, R2b, R2c, R3a, R3b, R4a, R4b, R5 and X are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer, as a sole agent or in combination with other active ingredients.
-
公开(公告)号：US11773070B2
公开(公告)日：2023-10-03
申请号：US17865236
申请日：2022-07-14
申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.
发明人： Manuel Ellermann , Stefan Nikolaus Gradl , Charlotte Christine Kopitz , Martin Lange , Adrian Tersteegen , Philip Lienau , Christa Hegele-Hartung , Detlev Sülzle , Timothy A. Lewis , Heidi Greulich , Xiaoyun Wu , Matthew Meyerson , Alex Burgin
IPC分类号： C07D273/04 , C07D413/10 , C07D413/12 , C07D417/10 , C07D471/04 , C07D491/107 , C07D495/10
CPC分类号： C07D273/04 , C07D413/10 , C07D413/12 , C07D417/10 , C07D471/04 , C07D491/107 , C07D495/10
摘要： The present invention provides dihydrooxydiazinone compounds of general formula (I)
in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.-
10.发明申请公开(公告)号：US20200247783A1
公开(公告)日：2020-08-06
申请号：US16635513
申请日：2018-08-02
申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.
发明人： Manuel Ellermann , Stefan Nikolaus Gradl , Charlotte Christine Kopitz , Martin Lange , Adrian Tersteegen , Philip Lienau , Detlev Sülzle , Timothy Lewis , Heidi Greulich , Xiaoyun Wu , Matthew Meyerson
IPC分类号： C07D403/10 , C07D405/10 , C07D401/10 , C07D237/04 , C07D413/10 , A61P35/04
摘要： The present invention provides 6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives of formula (I): The present invention provides 6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives of formula (I):
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.022 秒)
