- 专利标题： Methods for treating chemoresistant cancer-initiating cells
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申请号： US15745875申请日： 2016-07-28
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公开(公告)号： US11173173B2公开(公告)日： 2021-11-16
- 发明人: Rajeswari Kasi , Linheng Li , Xiuling Lu , John M. Perry , Gurusingham Sitta Sittampalam , Anuradha Roy , Xi C. He
- 申请人： UNIVERSITY OF CONNECTICUT , STOWERS INSTITUTE FOR MEDICAL RESEARCH , UNIVERSITY OF KANSAS
- 申请人地址： US CT Farmington; US MO Kansas City; US KS Lawrence
- 专利权人： UNIVERSITY OF CONNECTICUT,STOWERS INSTITUTE FOR MEDICAL RESEARCH,UNIVERSITY OF KANSAS
- 当前专利权人： UNIVERSITY OF CONNECTICUT,STOWERS INSTITUTE FOR MEDICAL RESEARCH,UNIVERSITY OF KANSAS
- 当前专利权人地址： US CT Farmington; US MO Kansas City; US KS Lawrence
- 代理机构： McDonnell Boehnen Hulbert & Berghoff LLP
- 国际申请： PCT/US2016/044584 WO 20160728
- 国际公布： WO2017/019914 WO 20170202
- 主分类号： A61K9/51
- IPC分类号： A61K9/51 ; A61K31/704 ; A61K31/513 ; A61K31/136 ; A61K31/4745 ; A61K45/06 ; A61K31/573 ; A61K9/00 ; A61K31/18 ; A61K31/475 ; A61K31/519 ; A61K31/7076 ; A61K31/708 ; A61K31/337 ; A61K33/242 ; A61K33/243 ; A61P35/02
摘要：
The disclosure provides methods of treating cancer by selectively inhibiting p-S552-β-catenin, p-T217-β-catenin, p-T332-β-catenin, and/or p-S675-β-catenin production and/or activity. Such methods also and/or limit cancer-initiating cells.