公开(公告)号：US20200339675A1

公开(公告)日：2020-10-29

申请号：US16793780

申请日：2020-02-18

Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH

Inventor： Robb Krumlauf ,  Debra Ellies

IPC: C07K16/28 ,  C07K14/705

Abstract: The present invention provides, inter alia, antibodies that modulate binding between Lrp5 and WISE or Lrp6 and WISE, but do not modulate binding between Lrp4 and WISE. Also provided are pharmaceutical compositions and kits containing such antibodies. Further provided are methods for preventing WISE binding to Lrp5 or Lrp6, but not WISE binding to Lrp4.

公开(公告)号：US20190194314A1

公开(公告)日：2019-06-27

申请号：US14653759

申请日：2013-12-20

Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH

Inventor： Robb Krumlauf ,  Debra Ellies

IPC: C07K16/28 ,  C07K14/705

CPC classification number: C07K16/28 ,  C07K14/705 ,  C07K2317/30 ,  C07K2317/76

Abstract: The present invention provides, inter alia, antibodies that modulate binding between Lrp5 and WISE or Lrp6 and WISE, but do not modulate binding between Lrp4 and WISE. Also provided are pharmaceutical compositions and kits containing such antibodies. Further provided are methods for preventing WISE binding to Lrp5 or Lrp6, but not WISE binding to Lrp4.

公开(公告)号：US20180072991A1

公开(公告)日：2018-03-15

申请号：US15683276

申请日：2017-08-22

Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH

Inventor： John M. PERRY ,  Linheng LI ,  Justin C. GRINDLEY

IPC: C12N5/0789 ,  A61K35/28

CPC classification number: C12N5/0647 ,  A61K35/28 ,  C12N2501/40 ,  C12N2501/415 ,  C12N2501/70 ,  C12N2502/11

Abstract: The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.

公开(公告)号：US09896659B2

公开(公告)日：2018-02-20

申请号：US14352410

申请日：2012-10-17

Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH

Inventor： John M Perry ,  Linheng Li ,  Aparna Venkatraman ,  Xi He

IPC: C12N5/00 ,  C12N5/02 ,  C12N5/18 ,  C12N5/0789 ,  A61K35/28

CPC classification number: C12N5/0647 ,  A61K35/28 ,  C12N2501/06 ,  C12N2501/415

Abstract: Methods and kits for expanding a stem cell population, particularly a hematopoietic stem cell population, in the presence of a DNA methyltransferase modulator and a Wnt pathway modulator are disclosed.

公开(公告)号：US20170362650A1

公开(公告)日：2017-12-21

申请号：US15536107

申请日：2015-12-18

Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH

Inventor： Julia Zeitlinger ,  Qiye He ,  Jeff Johnston

IPC: C12Q1/68

CPC classification number: C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/6853 ,  C12Q2535/122 ,  C12Q2537/159 ,  C12Q2563/179

Abstract: The present invention provides, inter alia, methods and kits for identifying where a polypeptide of interest binds in a genome. The methods include a) carrying out a chromatin immunoprecipitation coupled to exonuclease digestion (ChIP-exo) process with an antibody against the polypeptide of interest; (b) extracting a polynucleotide fragment to which the polypeptide of interest binds; (c) carrying out a library preparation protocol adapted from an individual nucleotide resolution UV cross-linking and immunoprecipitation (iCLIP) process on the ChIP-exo processed polynucleotide fragment; and (d) sequencing the resulting polynucleotides. The kits include: (a) reagents sufficient to carry out ChIP-exo; (b) reagents sufficient to carry out the library preparation protocol adapted from the iCLIP process; and (c) instructions for use.

公开(公告)号：US09771559B2

公开(公告)日：2017-09-26

申请号：US13897544

申请日：2013-05-20

Applicant: Stowers Institute for Medical Research

Inventor： John M. Perry ,  Linheng Li ,  Justin C. Grindley

IPC: C12N5/00 ,  C12N5/02 ,  C12N5/0789 ,  A61K35/28

CPC classification number: C12N5/0647 ,  A61K35/28 ,  C12N2501/40 ,  C12N2501/415 ,  C12N2501/70 ,  C12N2502/11

Abstract: The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.

公开(公告)号：US09321835B2

公开(公告)日：2016-04-26

申请号：US14012626

申请日：2013-08-28

Applicant: Stowers Institute for Medical Research

Inventor： Robb Krumlauf ,  Debra Ellies

IPC: C07K16/00 ,  C07K16/18 ,  C07K16/22 ,  C07K16/24 ,  C07K14/47 ,  C07K14/705 ,  C12N5/12 ,  C12N15/13 ,  A61K38/00 ,  A61K48/00 ,  A61K39/00

CPC classification number: C07K16/22 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/705 ,  C07K2317/24 ,  C07K2317/92

Abstract: The present invention is directed to isolated polypeptides and antibodies suitable for producing therapeutic preparations, methods, and kits relating to bone deposition. One objective of the present invention is to provide compositions that improve bone deposition. Yet another objective of the present invention is to provide methods and compositions to be utilized in diagnosing bone dysregulation. The therapeutic compositions and methods of the present invention are related to the regulation of Wise, Sost, and closely related sequences. In particular, the nucleic acid sequences and polypeptides include Wise and Sost as well as a family of molecules that express a cysteine knot polypeptide.

Abstract translation: 本发明涉及分离的多肽和抗体，其适用于生产与骨沉积相关的治疗制剂，方法和试剂盒。 本发明的一个目的是提供改善骨沉积的组合物。 本发明的另一个目的是提供用于诊断骨骼失调的方法和组合物。 本发明的治疗组合物和方法与Wise，Sost和密切相关的序列的调控有关。 特别地，核酸序列和多肽包括Wise和Sost以及表达半胱氨酸结多肽的分子家族。

公开(公告)号：US20130252338A1

公开(公告)日：2013-09-26

申请号：US13897544

申请日：2013-05-20

Applicant: Stowers Institute for Medical Research

Inventor： John M. PERRY ,  Linheng LI ,  Justin C. GRINDLEY

IPC: C12N5/0789

CPC classification number: C12N5/0647 ,  A61K35/28 ,  C12N2501/40 ,  C12N2501/415 ,  C12N2501/70 ,  C12N2502/11

Abstract: The present invention relates to methods for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods and compositions for expanding a stem cell population, particularly a hematopoietic stem cell population.

Abstract translation: 本发明涉及扩张干细胞群体的方法。 更具体地说，本发明尤其涉及用于扩增干细胞群体，特别是造血干细胞群体的方法和组合物。

公开(公告)号：US12186332B2

公开(公告)日：2025-01-07

申请号：US16914086

申请日：2020-06-26

Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH ,  THE CHILDREN'S MERCY HOSPITAL ,  UNIVERSITY OF KANSAS

Inventor： Linheng Li ,  John M. Perry ,  Fang Tao ,  Xi C. He ,  Anuradha Roy ,  Scott J. Weir ,  Tara Lin

IPC: A61K31/704 ,  A61K39/395 ,  A61P35/02 ,  C07K16/28

Abstract: The present disclosure provides, inter alia, methods for treating cancers including leukemia using low doses of an anthracycline such as doxorubicin.

公开(公告)号：US20240067718A1

公开(公告)日：2024-02-29

申请号：US18298105

申请日：2023-04-10

Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH

Inventor： Robb Krumlauf ,  Debra Ellies

IPC: C07K16/28 ,  A61K39/00 ,  C07K14/705

CPC classification number: C07K16/28 ,  A61K39/001102 ,  C07K14/705 ,  A61K39/001103 ,  A61K39/001116 ,  C07K2317/30 ,  C07K2317/76

Abstract: The present invention provides, inter alia, antibodies that modulate binding between Lrp5 and WISE or Lrp6 and WISE, but do not modulate binding between Lrp4 and WISE. Also provided are pharmaceutical compositions and kits containing such antibodies. Further provided are methods for preventing WISE binding to Lrp5 or Lrp6, but not WISE binding to Lrp4.