Invention Grant
- Patent Title: Method of treating cardiovascular disease and heart failure with modified relaxin polypeptides
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Application No.: US16287342Application Date: 2019-02-27
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Publication No.: US11185570B2Publication Date: 2021-11-30
- Inventor: Gene M. Dubowchik , Olafur S. Gudmundsson , Xiaojun Han , R. Michael Lawrence , Dasa Lipovsek , Cort S. Madsen , Claudio Mapelli , Paul E. Morin , Michael C. Myers
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agency: Baker, Donelson, Bearman, Caldwell & Berkowitz, PC
- Agent Robin L. Teskin
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/64 ; C07K1/107 ; A61K38/00 ; A61K47/64 ; A61P9/00 ; A61K45/06
Abstract:
The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
Public/Granted literature
- US20190256570A1 MODIFIED RELAXIN POLYPEPTIDES COMPRISING A PHARMACOKINETIC ENHANCER AND USES THEREOF Public/Granted day:2019-08-22
Information query
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