- 专利标题： Alkyl substituted triazole compounds as agonists of the APJ Receptor
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申请号： US16347924申请日： 2017-11-03
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公开(公告)号： US11191762B2公开(公告)日： 2021-12-07
- 发明人: Yinhong Chen , Mikkel V. Debenedetto , Paul John Dransfield , James S. Harvey , Jonathan Houze , Aarif Yusuf Khakoo , Su-Jen Lai , Zhihua Ma , Nobuko Nishimura , Vatee Pattaropong , Gayathri Swaminath , Wen-Chen Yeh , Philip Dean Ramsden , Ankit Sharma
- 申请人： AMGEN INC.
- 申请人地址： US CA Thousand Oaks
- 专利权人： AMGEN INC.
- 当前专利权人： AMGEN INC.
- 当前专利权人地址： US CA Thousand Oaks
- 代理机构： Fenwick & West LLP
- 国际申请： PCT/US2017/059828 WO 20171103
- 国际公布： WO2018/093576 WO 20180524
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; C07D405/14 ; A61K31/506 ; A61P9/04 ; A61K31/4439 ; A61K31/4196 ; C07D413/04 ; C07D401/04
摘要：
Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I), (II) where the definitions of the variables are provided herein.
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