Invention Grant
- Patent Title: Alkyl substituted triazole compounds as agonists of the APJ Receptor
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Application No.: US16347924Application Date: 2017-11-03
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Publication No.: US11191762B2Publication Date: 2021-12-07
- Inventor: Yinhong Chen , Mikkel V. Debenedetto , Paul John Dransfield , James S. Harvey , Jonathan Houze , Aarif Yusuf Khakoo , Su-Jen Lai , Zhihua Ma , Nobuko Nishimura , Vatee Pattaropong , Gayathri Swaminath , Wen-Chen Yeh , Philip Dean Ramsden , Ankit Sharma
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agency: Fenwick & West LLP
- International Application: PCT/US2017/059828 WO 20171103
- International Announcement: WO2018/093576 WO 20180524
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; C07D405/14 ; A61K31/506 ; A61P9/04 ; A61K31/4439 ; A61K31/4196 ; C07D413/04 ; C07D401/04
Abstract:
Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I), (II) where the definitions of the variables are provided herein.
Public/Granted literature
- US20190290647A1 ALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR Public/Granted day:2019-09-26
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