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公开(公告)号：US10689367B2
公开(公告)日：2020-06-23
申请号：US16347970
申请日：2017-11-03
申请人： AMGEN INC.
发明人： Yinhong Chen , Alan C. Cheng , Mikkel V. Debenedetto , Paul John Dransfield , James S. Harvey , Jonathan Houze , Aarif Yusuf Khakoo , Su-Jen Lai , Zhihua Ma , Vatee Pattaropong , Gayathri Swaminath , Charles Kreiman , David C. Moebius , Ankit Sharma
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , A61P9/04 , C07D417/14 , A61K45/06 , C07D401/12
摘要： Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the structures where the definitions of the variables are provided herein.
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公开(公告)号：US11191762B2
公开(公告)日：2021-12-07
申请号：US16347924
申请日：2017-11-03
申请人： AMGEN INC.
发明人： Yinhong Chen , Mikkel V. Debenedetto , Paul John Dransfield , James S. Harvey , Jonathan Houze , Aarif Yusuf Khakoo , Su-Jen Lai , Zhihua Ma , Nobuko Nishimura , Vatee Pattaropong , Gayathri Swaminath , Wen-Chen Yeh , Philip Dean Ramsden , Ankit Sharma
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , A61K31/506 , A61P9/04 , A61K31/4439 , A61K31/4196 , C07D413/04 , C07D401/04
摘要： Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I), (II) where the definitions of the variables are provided herein.
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公开(公告)号：US10150760B2
公开(公告)日：2018-12-11
申请号：US15945852
申请日：2018-04-05
申请人： AMGEN INC.
发明人： Xiaoqi Chen , Alan C. Cheng , Richard V. Connors , Mikkel V. Debenedetto , Paul John Dransfield , Zice Fu , James S. Harvey , Julie Anne Heath , Jonathan Houze , Ted C. Judd , David John Kopecky , Su-Jen Lai , Zhihua Ma , Nobuko Nishimura , Steven H. Olson , Vatee Pattaropong , Xiaodong Wang
IPC分类号： C07D405/14 , C07D403/14 , C07D409/14 , C07D401/14 , C07D403/04 , A61K45/06 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5383 , C07D498/04 , C07D405/04 , C07D471/04 , A61K31/437
摘要： Compounds of Formula V, salts thereof, tautomers thereof, and salts of the tautomers have the following structure and are useful compounds in preparing small molecule agonists of the APJ Receptor: where the definitions of the variables are provided herein.
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公开(公告)号：US09656998B2
公开(公告)日：2017-05-23
申请号：US15298686
申请日：2016-10-20
申请人： AMGEN INC.
发明人： Ning Chen , Xiaoqi Chen , Richard V. Connors , Jeffrey Deignan , Paul John Dransfield , Xiaohui Du , Zice Fu , Julie Anne Heath , Daniel B. Horne , Jonathan Houze , Matthew R. Kaller , David John Kopecky , Su-Jen Lai , Zhihua Ma , Lawrence R. McGee , Julio C. Medina , Jeffrey T. Mihalic , Nobuko Nishimura , Steven H. Olson , Vatee Pattaropong , Xiaodong Wang , Kevin Yang , Mikkel V. Debenedetto , Robert P. Farrell , Simon J. Hedley , Ted C. Judd
IPC分类号： C07D213/82 , C07D241/24 , C07D401/12 , C07D401/14 , C07D401/04 , C07D413/04 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K45/06 , C07B57/00 , C07B59/00 , C07D211/54 , C07D213/71 , C07D239/26 , C07D239/30 , C07D241/12 , C07D249/08 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/695
CPC分类号： A61K31/506 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/513 , A61K31/695 , A61K45/06 , C07B57/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07C311/13 , C07D211/54 , C07D213/61 , C07D213/71 , C07D213/82 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D241/18 , C07D241/24 , C07D249/08 , C07D295/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/08
摘要： Compounds of Formula V, salts thereof, tautomers thereof, and salts of the tautomers are useful intermediates in the synthesis of agonists of the APJ Receptor. Compounds of Formula V have the following structure: where the definitions of the variables are provided herein.
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公开(公告)号：US11299479B1
公开(公告)日：2022-04-12
申请号：US17068518
申请日：2020-10-12
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel V. Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley Paul Morgan , Joshua Payette , Antonio Romero , David St. Jean, Jr. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D413/12 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D209/52
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US11254658B2
公开(公告)日：2022-02-22
申请号：US16833321
申请日：2020-03-27
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Mikkel V. Debenedetto , Justin Malinowski , Joshua Payette , Antonio Romero , David St. Jean, Jr.
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D209/52 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US20200223830A1
公开(公告)日：2020-07-16
申请号：US16833336
申请日：2020-03-27
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel V. Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley Paul Morgan , Joshua Payette , Antonio Romero , David St. Jean, JR. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D209/52 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US20180222895A1
公开(公告)日：2018-08-09
申请号：US15945852
申请日：2018-04-05
申请人： AMGEN INC.
发明人： Xiaoqi Chen , Alan C. Cheng , Richard V. Connors , Mikkel V. Debenedetto , Paul John Dransfield , Zice Fu , James S. Harvey , Julie Anne Heath , Jonathan Houze , Ted C. Judd , David John Kopecky , Su-Jen Lai , Zhihua Ma , Nobuko Nishimura , Steven H. Olson , Vatee Pattaropong , Xiaodong Wang
IPC分类号： C07D405/14 , C07D409/14 , C07D403/14 , C07D403/04 , C07D401/14 , A61K45/06 , A61K31/4439 , A61K31/437 , A61K31/506 , A61K31/5383 , C07D498/04 , C07D405/04 , C07D471/04 , A61K31/497
CPC分类号： C07D405/14 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D409/14 , C07D471/04 , C07D498/04
摘要： Compounds of Formula V, salts thereof, tautomers thereof, and salts of the tautomers have the following structure and are useful compounds in preparing small molecule agonists of the APJ Receptor: where the definitions of the variables are provided herein.
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公开(公告)号：US20160340336A1
公开(公告)日：2016-11-24
申请号：US15158174
申请日：2016-05-18
申请人： AMGEN INC.
发明人： Ning Chen , Xiaoqi Chen , Yinhong Chen , Alan C. Cheng , Richard V. Connors , Jeffrey Deignan , Paul John Dransfield , Xiaohui Du , Zice Fu , Julie Anne Heath , Daniel B. Horne , Jonathan Houze , Matthew R. Kaller , Aarif Yusuf Khakoo , David John Kopecky , Su-Jen Lai , Zhihua Ma , Lawrence R. McGee , Julio C. Medina , Jeffrey T. Mihalic , Nobuko Nishimura , Steven H. Olson , Vatee Pattaropong , Gayathri Swaminath , Xiaodong Wang , Kevin Yang , Wen-Chen Yeh , Mikkel V. Debenedetto , Robert P. Farrell , Simon J. Hedley , Ted C. Judd , Frank Kayser
IPC分类号： C07D401/14 , C07D213/82 , C07D241/24 , C07D239/30 , C07D239/26 , C07D401/04 , A61K31/4439 , A61K31/506 , C07D413/14 , C07B59/00 , A61K31/497 , A61K31/513 , C07D471/04 , A61K31/444 , C07D417/14 , C07B57/00 , C07D405/14 , A61K31/501 , C07D249/08 , C07D241/12 , C07D213/71 , C07D211/54 , A61K45/06
CPC分类号： A61K31/506 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/513 , A61K31/695 , A61K45/06 , C07B57/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07C311/13 , C07D211/54 , C07D213/61 , C07D213/71 , C07D213/82 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D241/18 , C07D241/24 , C07D249/08 , C07D295/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/08
摘要： Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
摘要翻译： 其中在这里提供变量的定义。
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公开(公告)号：US10906890B2
公开(公告)日：2021-02-02
申请号：US16347955
申请日：2017-11-03
申请人： AMGEN INC.
发明人： Ning Chen , Yinhong Chen , Mikkel V. Debenedetto , Paul John Dransfield , James S. Harvey , Julie Anne Heath , Jonathan Houze , Aarif Yusuf Khakoo , Su-Jen Lai , Zhihua Ma , Nobuko Nishimura , Vatee Pattaropong , Gayathri Swaminath , Wen-Chen Yeh , Charles Kreiman
IPC分类号： C07D403/14 , C07D239/24 , C07D241/12 , C07D249/14 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D239/26 , A61P9/04 , C07D401/14
摘要： Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I), (II) where the definitions of the variables are provided herein.
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